hematopoietic stem cell transplantation (hsct) has been practiced for more than 30 years. hematological malignanciesare the main indications for this treatment. however, its indications in adults are different from children.advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of hsct in children. multi-center c...

traumatic brain injury (tbi) is physical damage to the brain structure which has a high global rate of mortality and morbidity. tbi can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. microglia can differentiate into m1 macrophages or m2 macrophages following the changes in biochemical properties of brain tissue. m1 sub type ...

blood brain barrier (bbb) is a specialized non fenestrate barrier that formation by the endothelial cells and controls the transportation of the cells and molecules in to the brain. reducing in function of bbb is one of disruptions in neurological diseases like multiple sclerosis. endothelial progenitor cell (epc) help to the bbb to control the diapedesis of inflammatory cells & molecules in to...

background: early clinical investigations indicate that an infusion of autologous bone-marrow cells into the infarct-related coronary artery is feasible after acute myocardial infarction. there is increasing evidence that cell transplantation may improve the perfusion and contractile function of the ischemic myocardium . the present study reports primarily the safety of intracoronary bone marro...

introduction: neuroblastoma is the most common extracranial solid tumor in children, accounting for 8% to 10% of all childhood cancers. significantly, autologous transplantation appeared to have the largest impact on survival for the high risk subset of patients, such as those with n-myc amplified metastatic disease diagnosed after age 2 years. patients and methods: this study includes high ris...

peripheral blood stem cell transplantation (pbsct) is an effective treatment for hematological malignancies. mobilization of peripheral blood progenitor cells performs in different ways among transplantation centers. forceful mobilization schedules are comprised of growth factor alone, chemotherapy along with growth factor and also, a newly combination of novel agent such as plerixafor with any...

neurotrauma is one of the main medical problems that affect considerable number of population especially young persons in all countries. neurotrauma not only is a serious threat for life but also creates various disabilities and consequently imposes large costs to society. following central nervous system (cns) injury, tissue damage occurs via primary and secondary mechanisms. despite many atte...

in spite of serious cardiotoxicity side-effects, doxorubicin is frequently used for treatment of several types of cancers. isolated human adult cardiomyocytes could be the best model for assessing drug-induced cardiotoxicity, while harvesting mature cardiomyocytes is restricted by some limitations such as biopsy size, cell numbers, viability, proliferative capacity and their disability to be pa...

introduction: human hematopoietic stem cells (hhscs) have been used for transplantation in hematologic failures. because the number of hhscs per cord blood unit is limited, the expansion of these cells is important for clinical application. it has been reported that cytokines and feeder layer provide a perspective to in vitro expansion of hhscs. in this regard, cord blood cd34+ cells expanded a...

this paper summarizes the proceedings of a 1 day national symposium entitled “reproductive biology, stem cells biotechnology and regenerative medicine” held at shahid sadoughi university of medical sciences, yazd, iran on 3rd march 2016. here, we collected the papers that presented and discussed at this meeting by specialists that currently researched about the overlaps of the fields of reprodu...