This paper describes an integrated radial basis function network (IRBFN) method for the numerical modelling of the dynamics of strain localization due to strain softening in quasi-brittle materials. The IRBFN method is a truly meshless method that is based on an unstructured point collocation procedure. The integration approach is the key to achieving accurate function derivatives necessary for...

We use the spectral-element method to simulate strong ground motion throughout the Taipei metropolitan area. Mesh generation for the Taipei basin poses two main challenges: (1) the basin is surrounded by steep mountains, and (2) the city is located on top of a shallow, low-wave-speed sedimentary basin. To accommodate the steep and rapidly varying topography, we introduce a thin high-resolution ...

Since the discovery of the stimulating effect of corn steep liquor on penicillin fermentation, various lactosesteep liquor media have been used in penicillin fermentations. The requirements for a good penicillin fermentation are fulfilled by the steep liquor-lactose media by virtue of its composition (Johnson, 1952). The production of penicillin on a chemically defined medium (Jarvis and Johnso...

Many screening hits inhibit enzymes with steep dose-response curves, which are considered pathological. Three models might explain these curves: multisite binding, an inhibitor phase transition, or stoichiometric inhibition caused by a high enzyme to Kd ratio. Experiments with promiscuous aggregators, for which steep curves are common, suggest that these curves owe to stoichiometric inhibition,...