Steady-state enzyme kinetics is a cornerstone technique of biochemistry and related sciences since it allows the characterization quantification behaviour. Enzyme widely used to investigate physiological role enzymes, determine effects mutations characterize inhibitors. Well-known examples inhibitors treat diseases include anti-infectives (e.g., penicillin, clavulanic acid HIV protease inhibito...

The importance in promoting, sustaining industries, manufacturing systems and economy through reliability measurement has become an area of interest. Reliability is one of the most important factors in any successful industries and manufacturing settings. In this paper, we study the reliability of three different repairable redundant network flow systems. First order differential equations meth...

sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. it is of interest to study its effect on red cell indices beside haemoglobin concentration.the objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia.we conducted a cross-sectional study including 97 children with sickle cell anaemia aged s...

background: sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. the purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. methods: a cross-sectional study was conducted among the sickle cell patients atten...

We consider a stochastic PDE with localized coherent structures known as kinks. The availability of exact results for the steady state and increasing computer power means that precise quantitative comparison between theory and numerics is possible. One of the quantities of interest is the steady-state density of kinks, maintained by a balance between nucleation and annihilation of kink-antikink...

is paper considers the M/M/NN repairable queuing system. e customers’ arrival is a Poisson process. e servers are subject to breakdown according to Poisson processes with different rates in idle time and busy time, respectively. e breakdown servers are repaired by repairmen, and the repair time is an exponential distribution. Using probability generating function and transform method, we ob...

This paper studies the nonlinear vibration analysis of a simply supported Euler-Bernoulli beam resting on a nonlinear elastic foundation under compressive axial load using nonlinear normal modes concept in the case of three-to-one (3:1) internal resonance. The beam’s governing nonlinear PDE of motion and also its boundary conditions are derived and then solved using the method of Multiple Time ...

Histone N(ϵ)-methyl lysine demethylases are important in epigenetic regulation. KDM4E (histone lysine demethylase 4E) is a representative member of the large Fe(II)/2-oxoglutarate- dependent family of human histone demethylases. In the present study we report kinetic studies on the reaction of KDM4E with O2. Steady-state assays showed that KDM4E has a graded response to O2 over a physiologicall...

In this paper, we studied and formulated the relapsed SIR model of a constant size population with standard incidence rate. Also, the optimal control problem with treatment and vaccination as controls, subject to the model is formulated. The analysis carried out on the model, clearly showed that the infection free steady state is globally asymptotically stable if the bas...