Exopolysaccharide (EPS) biopolymers produced by microorganisms play a crucial role in the environment such as health and bio-nanotechnology sectors, gelling agents in food and cosmetic industries in addition to bio-flocculants in the environmental sector as they are degradable, nontoxic. This study focuses on the improvement of EPS production through manipulation of different culture and enviro...

Drug combination is a critically important therapeutic approach for complex diseases such as cancer and HIV due to its potential for efficacy at lower, less toxic doses and the need to move new therapies rapidly into clinical trials. One of the key issues is to identify which combinations are additive, synergistic, or antagonistic. While the value of multidrug combinations has been well recogni...

We present a sensitivity study approach to evaluate the effects of interconnect variations on the performance of large, complicated circuits. The approach uses highly efficient designed experiments. The results from the study of a multiplier circuit are presented as an example. 1.0 Introduction TodayÆs submicron circuits require a sensitivity study of interconnect variation on circuit performan...

This paper proposes a hierarchical nonlinear approximation scheme for scalar-valued multivariate functions, where the main objective is to obtain an accurate approximation with using only very few function evaluations. To this end, our iterative method combines at any refinement step the selection of suitable evaluation points with kriging, a standard method for statistical data analysis. Parti...

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In this chapter we draw connections between two seemingly opposing approaches to probability and statistics: evidential probability on the one hand and objective Bayesian epistemology on the other.