BACKGROUND An intravenous course of unfractionated heparin adjusted on the basis of the activated partial thromboplastin time is the initial treatment of choice for most patients with venous thromboembolism. Recently introduced low-molecular-weight heparin preparations can be administered subcutaneously, once or twice daily, without laboratory monitoring. We quantitatively assessed the relative...

BACKGROUND Dendritic cells (DC) induce tumor or pathogen-specific T cell responses in humans. Several laboratories have developed culture systems, including maturation factors for human DC from peripheral blood monocytes. We comprehensively compared standard maturation stimulus, an autologous monocyte-conditioned medium (MCM), with heparin for their ability to promote uniformly mature DC that e...

Heparin-İnduced Thrombocytopenia (HIT) is a life-threatening complication that occurs in small percentage of exposed patients (e.g. unfractionated heparin, Low Molecular Weight Heparin [LMWH]) regardless dose and treatment management.

Heparin-induced thrombocytopenia is a well-known, life-threatening complication that occurs in 5% of patients exposed to heparin. It causes thrombocytopenia in roughly 85% to 90% of affected individuals, with expected recovery in approximately 4 to 10 days following heparin withdrawal. However, there is an entity known as refractory heparin-induced thrombocytopenia with thrombosis in which pati...

The effect of heparin therapy was followed in 50 patients treated for thrombo-embolic disease. Individual response to a standard dose of 40,000 units of heparin daily showed a considerable variation and the effect was not constant on subsequent days. Five of the 50 patients developed a serious haemorrhage. It is proposed that to ensure the adequacy of treatment detectable levels of heparin shou...

BACKGROUND Heparin and low molecular weight heparin are the most frequently used antithromboembolic drugs in fractures. OBJECTIVES We aimed to compare the effects of heparin and enoxaparin, which are used as standard treatment, on viability in degloving injuries. METHODS Thirty rats were used in the study. Three groups were composed including 10 rats in each group. Degloving injuries were f...

samples and hemolysis can be responsible for LD measurements with poor precision in addition to higher LD activity values (7, 8). To investigate these effects, we performed LD measurements with serum-gel (Sarstedt Monovette prod. no. 02.1388), lithium-heparin-gel (same as given above), and lithium-heparin tubes (Sarstedt Monovette prod. no. 01.1604.400). Blood samples were collected from the sa...