Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disease of the kidneys and is marked by progressive cyst growth and decline in kidney function, resulting in end-stage renal disease (ESRD). Hypertension is thought to be a significant modifying factor in the progression of renal failure in ADPKD. A number of genetic variations involved in reninangiotensin-aldoste...

Oligomeganephronia is classified as a subgroup of renal hypoplasia, characterized by histopathologic abnormalities which progress to end-stage renal disease (ESRD) by school age. We describe three adult cases of oligomeganephronia who have not yet developed ESRD. We performed a renal biopsy in all of them. The pathological features, consisting of a reduced number of enlarged glomeruli, were dia...

BACKGROUND Longer nephrology care before end-stage renal disease (ESRD) has been linked with better outcomes. METHODS We investigated whether longer pre-end-stage renal disease (ESRD) nephrology care was associated with lower mortality at both the patient and state levels among 443 761 incident ESRD patients identified in the USA between 2006 and 2010. RESULTS Overall, 33% of new ESRD patie...

Renal disease is common throughout the world. In the United States alone, almost 100,000 people began renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2001(Kimmel & Peterson, 2005); by 2008, this number had increased to 485,000 patients (Collins et al., 2009). More than 90% of these patients were started on hemodialysis (HD), while only 8.5% began RRT with peritoneal dialys...

background: infl ammatory cytokines such as interleukin-6 (il-6) and tumor necrosis factor-alpha (tnf-α) are elevated in end-stage renal disease (esrd). il-6 and tnf-α are toxins which deteriorate renal function, and their pathogenic role has been confi rmed in cardiovascular and oral diseases. this study was designed to investigate the salivary levels of il-6 and tnf-α in patients with esrd un...

background :hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (esrd). vitamin b12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients.   methods : using all randomized controlled trials (rcts), clinical trials and pre-post-trial studi...

Patients with end-stage renal disease (ESRD) had a higher risk of developing cardiovascular disease, including peripheral artery (PAD). The presence PAD in hemodialysis patients leads to an increase the incidence amputation and mortality. However, early diagnosis is still challenging. Clinical manifestation ESRD often atypical manifestations present severe manifestations. We reported case right...

BACKGROUND Renal involvement is a serious manifestation of systemic lupus erythematosus (SLE); it may portend a poor prognosis as it may lead to end-stage renal disease (ESRD). The purpose of this study was to determine the factors predicting the development of renal involvement and its progression to ESRD in a multi-ethnic SLE cohort (PROFILE). METHODS AND FINDINGS PROFILE includes SLE patie...

Although malignancy is a fatal complication of end-stage renal disease (ESRD) requiring haemodialysis, successful treatment of haematological malignancies has been rarely reported. We describe the case of a 64-year-old man who presented with non-Hodgkin's lymphoma (NHL; clinical stage, IVB) concomitant with ESRD. Before chemotherapy, haemodialysis was initiated, and one course of dose-adjusted ...