Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome/IL-1β pathway is accompanied with an increased inflammatory response and abno...

Non-alcoholic fatty liver disease (NAFLD) affects almost one third of adults in European countries. A well-known factor of influence is overnutrition and insulin resistance (Farrell and Larter, 2006). In contrast, much less attention is given to drug induced steatosis (Chen et al., 2014). It is crucial that steatosis inducing compounds are detected and excluded early in drug development (Hewitt...

Regulating the adipogenic differentiation mechanism is a valid and promising to battle obesity. Natural products, especially phytochemicals as nutraceuticals, are important lead molecules with significant activities against Loliolide monoterpenoid hydroxyl lactone found in many dietary plants. The effect of loliolide on yet be determined. Therefore, present study aimed evaluate its anti-adipoge...

The FADS1 and FADS2 genes in the FADS cluster encode the rate-limiting enzymes in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Genetic variation in this region has been associated with a large number of diseases and traits many of them correlated to differences in metabolism of PUFAs. However, the causative variants leading to these associations have not been identified. ...

The main purpose of this study is to examine the effect of caffeine on lipid accumulation in human hepatoma HepG2 cells. Significant decreases in the accumulation of hepatic lipids, such as triglyceride (TG), and cholesterol were observed when HepG2 cells were treated with caffeine as indicated. Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR ...

In order to determine anti-adipogenic effect, this study investigated 1β-hydroxy-2-oxopomolic acid (HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding prote...

We investigated the protective effect of carvacrol against high-fat-diet-induced hepatic steatosis in mice and the potential underlying molecular mechanisms. Mice were fed a normal diet, high-fat diet, or carvacrol-supplemented high-fat diet for 10 weeks. Compared to mice fed the high-fat diet, those fed the carvacrol-supplemented diet showed significantly lower hepatic lipid levels and reduced...

The objective of this study is to determine the effects dietary replacement soybean oil (SO) with rubber seed (RSO) on growth performance, carcass trait, and lipid metabolism in Pekin ducks. A total 160 1-day-old ducks were randomly allocated four experimental treatments fed diets different ratios SO RSO as follows: 3:0 (control), 2:1, 1:2, 0:3. Dietary supplementation had no effect their perfo...