BACKGROUND Disorders associated with excessive swelling of the lower extremities are common. They can be associated with pain, varicose veins, reduced blood pressure when standing and may cause syncope or fainting. The common physical remedy to these disorders is the use of compression stockings and pneumatic compression leg massagers, which both attempt to limit blood pooling and capillary fil...

One would think that risk factors for transient ischemic attack (TIA) and asymptomatic carotid bruit (ACB) would be similar. In our referral population and in several previously reported cohort populations, however, men outnumber women among patients with TIA. In contrast, women outnumber men among patients with ACB. We found in two independent populations that women with ACB are up to 5.7 time...

Inversion of magnetic data is an important step towards interpretation of the practical data. Smooth inversion is a common technique for the inversion of data. Physical bound constraint can improve the solution to the magnetic inverse problem. However, how to introduce the bound constraint into the inversion procedure is important. Imposing bound constraint makes the magnetic data inversion a n...

Adaptive mesh refinement (AMR) applications refine small regions of a physical space. As a result, when AMR data has to be stored in a file, writing data involves storing a large number of small blocks of data. Chombo is an AMR software library for solving partial differential equations over block-structured grids, and is used in large-scale climate and fluid dynamics simulations. Chombo’s curr...

BACKGROUND We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versatile, non-invasive, and accessible tool to study pharmacokinetic parameters of MNPs, such as circulation time, in real time. We synthesized and monitored manganese doped iron ox...

BACKGROUND Tangle-predominant dementia (TPD) is characterized neuropathologically by numerous neurofibrillary tangles in the limbic areas with no or occasional senile plaques throughout the brain. TPD is an under-recognized disease, while it is a common cause of dementia in those over 80 years of age. In the present study, we describe hyperphosphorylated tau (tau) accumulation in the nucleus ac...

| In this paper, we consider robust inversion of linear operators with convex constraints. We present an iteration that converges to the minimum norm least squares solution; a stopping rule is shown to regularize the constrained inversion. A constrained Laplace inversion is computed to illustrate the proposed algorithm.

The objective of the present study was to examine the effects of perfusion of dopamine (DA) D1- and D2-like receptor agonists in the nucleus accumbens (ACB) on the long-loop negative feedback regulation of mesolimbic somatodendritic DA release in the ventral tegmental area (VTA) of Wistar rats employing ipsilateral dual probe in vivo microdialysis. Perfusion of the ACB for 60 min with the D1-li...

results of velocity structure modeling in the earth's crust using a comparison approach of receiver function analysis and joint inversion of receiver functions with surface wave dispersion data are presented in this paper. seismograms of the teleseismic events that have been recorded on a broadband seismic station in the central alborz were used for data processing. velocity models that we...

Neurons in the ventral tegmental area (VTA) that innervate the nucleus accumbens (Acb) constitute the so-called mesoaccumbens system. Increased activity by these neurons is correlated with the expectation and achievement of reward. The mesoaccumbens projection neurons are regarded as a central node in the brain networks that regulate drive and hedonic experience, and their dysregulation is a co...