HNSCC: head and neck SCC SCC: squamous cell carcinoma SSS: secondary SCC of the skin INTRODUCTION Metastatic squamous cell carcinoma (SCC) to the skin, also known as secondary SCC of the skin (SSS), is a rare entity that represents advanced disease and carries a poor prognosis. The most commonly reported primary sources for metastatic SCC to the skin are head and neck cancers of the larynx, oro...

Primary squamous cell carcinoma (SCC) of the thyroid gland is a rare diagnosis, since there is no squamous epithelium in the thyroid gland. SCC of the thyroid is highly aggressive with a poor prognosis. We present a case of primary SCC of the thyroid: this 88-year-old male patient had a history of hyperthyroidism which was treated with radioactive iodine 25 years earlier. Whether this treatment...

Cancer of the oral cavity is a widely prevalent disease and has been listed as sixth most common cancer worldwide [1]. Squamous cell carcinoma (SCC) accounts for about 90% all these cases [2]. Despite tremendous research over last 70 years, overall prognosis remains at 50% with no gender difference [3].

Purpose: Lung adenocarcinoma and lung squamous cell carcinoma (SCC) are the most common non–small cell lung cancer (NSCLC) subtypes. This study was designed to determine whether reduced expression of TGFb type II receptor (TGFbRII) promotes lung adenocarcinoma and SCC

OBJECTIVE The objective of this study was to evaluate the clinical benefits of routine squamous cell carcinoma antigen (SCC-Ag) monitoring of patients with locally advanced cervical squamous cell carcinoma treated with radiation or chemoradiation. METHODS A total of 53 patients with recurrent cervical squamous cell carcinoma treated with radiotherapy or chemoradiation were enrolled in this st...

Cemiplimab is the first PD-1 inhibitor approved in United States for treatment of metastatic or locally advanced cutaneous squamous cell carcinoma (SCC) and basal (BCC), but not melanoma. We describe a case amelanotic melanoma (AM) developing patient on cemiplimab therapy invasive SCC. Cutaneous AM rare subtype that shows little no melanin pigmentation clinical histological examination thus oft...

5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent that inhibits the growth and initiates the apoptosis of epithelial tumors, including squamous cell carcinoma of the head and neck region. However, resistance to this drug is often observed in a clinical setting. The primary mode of action of 5-FU is believed to be the inhibition of thymidylate synthase. Overexpression of the enzymes ...

Oral cavity squamous cell carcinoma (OC-SCC) is the most common malignancy of the head and neck (excluding nonmelanoma skin cancer). Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma (OP-SCC), with a marked increase in lesions related to human papillomavirus infection. This update presents the latest evidence regarding OC-SCC and OP-SCC. In parti...

abstract   squamous cell carcinoma (scc) is the most common malignant tumors of oral cavity. the ratio of men to women is about 2: 1. generally, it   is admitted that 60% of carcinoma of the mandibular gingival are located in the posterior of premolars. gingiva is one of the less common sites of oral squamous cell carcinoma (oscc). due to the variable clinical and behavioral presentations, it c...

No effective tumor markers are available for squamous cell carcinoma of the head and neck region with the exception of immunosuppressive acidic protein (IAP). Recently, TA-4 was developed by Kato et al. as a marker of uterine cervical squamous cell carcinoma. Furthermore, squamous cell carcinoma related antigen (SCC antigen) was isolated from the tissue of liver metastasis of this carcinoma, an...