Derivatization of spirooxindole having triazole and ferrocene units was achieved by the [3 + 2] cycloaddition (32CA) reaction approach. Reacting respective azomethine ylide (AY) intermediate generated in situ with ethylene derivative produced novel asymmetric cycloadducts four contiguous carbons an overall high chemical yield excellent regioselectivity diastereoselectivity. X-Ray single-crystal...

Ligation-mediated PCR was employed to quantify cyclobutane pyrimidine dimer (CPD) formation at nucleotide resolution along exon 2 of the adenine phosphoribosyltransferase (aprt) locus in Chinese hamster ovary (CHO) cells following irradiation with either UVA (340-400 nm), UVB (295-320 nm), UVC (254 nm) or simulated sunlight (SSL; lambda > 295 nm). The resulting DNA damage spectrum for each wave...

A new spirooxindole hybrid engrafted imidazo[2,1-b]thiazole core structure was designed and achieved via [3+2] cycloaddition reaction approach. One multi-component between the ethylene derivative based scaffold with 6-Cl-isatin secondary amine under heat conditions afforded desired compound in a stereoselective manner. The relative absolute configuration assigned on single-crystal X-ray diffrac...

Abstract This account describes the strategies for synthesis of functionalized spirooxindole polycycles, including enantiomerically enriched forms, that we have developed and reported. The syntheses these complex molecules were accomplished in a few steps starting from relatively simple oxindole derivatives other reactants. Organocatalytic reactions involved kinetic resolution or dynamic transf...