In this study, we designed and developed a new drug delivery system of multifunctional composite microcapsules for oral administration of insulin. Firstly, in order to enhance the encapsulation efficiency, insulin was complexed with functional sodium deoxycholate to form insulin-sodium deoxycholate complex using hydrophobic ion pairing method. Then the complex was encapsulated into poly(lactide...

Repair of large bone defects is a major challenge, requiring sustained stimulation to continually promote bone formation locally. Bone morphogenetic protein 2 (BMP-2) plays an important role in bone development. In an attempt to overcome this difficulty of bone repair, we created a delivery system to slowly release human BMP-2 cDNA plasmid locally, efficiently transfecting local target cells an...

Pigs are believed to be one of the important sources of emerging human and swine influenza viruses (SwIV). Influenza virus conserved peptides have the potential to elicit cross-protective immune response, but without the help of potent adjuvant and delivery system they are poorly immunogenic. Biodegradable polylactic-co-glycolic acid (PLGA) nanoparticle (PLGA-NP) based vaccine delivery system e...

Drug Delivery In article number 2000069, Boaz Mizrahi and co-workers report a new nano delivery system that is based on injectable liquid copolymer. The copolymer, starPEG-PLGA (red blue in the image) mixed with drug (green spheres without any solvents or excipients. After mixture injected into body, copolymer self-assembles situ well-defined nanoparticles.

As a means of treating lymphatic metastasis from lung cancer, the pharmacokinetics and therapeutic effects of an intrapleural (ipl) implantable drug delivery system consisting of a gelatin sponge impregnated with polylactide-co-glycolide paclitaxel (PLGA-PTX) microspheres were studied. PLGA-PTX with 7% (w/w) drug loading were incorporated into gelatin matrix. The pharmacokinetics were studied i...

The Cannabidiol (CBD) are extensively used owing to their potent antibacterial effects. We developed CBD-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles using an emulsion process technology, resulting informing the PLGA@CBD nanoparticles. parameters were optimized three-dimensional surface plots. When scaled up under optimal conditions, corresponding loading content efficiency 16.51%...

Introduction Modified gene activities (transcription alterations) are known to precede phenotypic changes that are associated with normal (developmental) and pathophysiological (disease) processes in all biological systems especially in the brain. Procedures to evaluate gene activity in the brain are not routinely performed because the techniques used rely on biopsy or autopsy samples. As the r...

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections worldwide. An effective RSV vaccine requires the induction of mucosal immunity which is a major hurdle. Development of polymeric nanoparticle delivery systems is one of the strategies to overcome this hurdle. PLGA, a biodegradable copolymer is FDA approved and chitosan, a mucoadhesive polym...

Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and ...

In this study, multifunctional theranostic agents for photoacoustic (PA), ultrasound (US), fluorescent imaging, and for therapeutic drug delivery were developed and tested. These agents consisted of a shell made from a biodegradable Poly(lactide-co-glycolic acid) (PLGA) polymer, loaded with perfluorohexane (PFH) liquid and gold nanoparticles (GNPs) in the core, and lipophilic carbocyanines fluo...