BACKGROUND The aim of the study was to determine the relationship between the presence of p.G60 = polymorphism (c.180C > T; rs497078) CTRC and the incidence together with the clinical course of acute pancreatitis (AP). METHODS Two hundred ninety-nine people suffering from AP and 417 healthy volunteers were subjected to the study. DNA was isolated from blood samples. RESULTS CTRC p.G60 = pol...

Familial aggregation of CP suggests genetic factors for disease without definitive mode of inheritance. The hypothesized primary putative gene for CP includes SPINK1, CTSB, CTRC, PRSS1 and CFTR. These genes interact with each other and exhibit a variable phenotype in patients. The present report describes a male adult aged 42 years with a complaint of severe recurrent pain in the abdomen and we...

Abstract Background Treatment with thiopurines may be associated different adverse effects, including acute pancreatitis. Risk factors for developing pancreatitis due to in patients Inflammatory Bowel Disease (IBD) are not clearly identified, underlying genetic predisposition being a possible cause. Our aim was evaluate predictive pharmacogenetic risk of IBD treated thiopurines. Methods were id...