Abstract Type-1 neurofibromatosis (NF1) is a neurocutaneous syndrome classically known as peripheral NF to distinguish it from type-2 (central NF). Its main characteristic the high predisposition growth of multiple tumors, which specially arouses interest spinal surgeons due presence cord compression and deformities. Considering this, we have performed comprehensive review, with illustrative ca...

Spinal cord tumors lead to neurological morbidity and mortality. Being able obtain morphometric quantification (size, location, growth rate) of the tumor, edema, cavity can result in improved monitoring treatment planning. Such requires segmentation these structures into three separate classes. However, manual three-dimensional is time consuming, tedious prone intra- inter-rater variability, mo...

Postoperative paraplegia is a rare complication after epidural analgesia and often occurs with spinal hematoma or cord injury. We present the case of a 16-year-old girl who suffered from a tumor mass in the neck and abdomen who underwent gynecologic operation. Preoperatively, liver metastasis was found by computed tomography. Pathologic findings revealed that the abdominal mass was an ovarian d...

Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. Studies showed that individuals with SCI has a clear tendency to vitamins level change. The aim of this study was to review the vitamins level in spinal cord injury. Vitamins C level decrease in the injured spinal cord patient. Vitamins C hav...

initial presentation of diastematomyelia is rarely seen in adults. the purpose of this case report is to present a case of clinically silent diastematomyelia unrecognized into adulthood and review of the literature. a 53-year-old persian man was admitted to our hospital with gait disturbance, weakness of the right lower extremity, sensory loss of the left and right lower extremity of two weeks’...

Percutaneous vertebroplasty is a minimally invasive surgical technique for the treatment of spinal damage and pathological compression fractures. Iodine-125 (I-125) particles can inhibit the uncontrolled proliferation of tumor cells to achieve anti-tumor effects. We report treating a spinal cord compression and T5 metastatic lung cancer patient through percutaneous vertebroplast...

Background: Following spinal cord injury, reactive astrocytes upregulate chondroitin sulfate proteoglycans (CSPGs) which act as a barrier to neuronal repair and regeneration. Therefore, enzymatic digestion of CSPGs by chondroitinase ABC (cABC) is a key strategy in the treatment of spinal cord injury. Furthermore, cABC has been shown to attenuate post spinal cord injury inflamma...

Compound action potential (CAP) of spinal cord represents valuable properties of neural fibers including excitability, rate of myelination and membrane integrity. These properties are measured using amplitude, latency and area under curve of CAPs recorded from spinal cord. Here, the isolated spinal cord was set in a double sucrose gap (DSG) chamber and its response to intracellular stimulation ...

Schwannoma originates from the sheath of spinal cord roots neurilemma or Schwann cells (so it is mainly called neurilemmoma or Schwannoma) and makes one third of primary spinal cord tumours [1-6]. The tumour localization is in various parts of spinal cord, but prevailsin cervical and thoracic, rare in lumbar and sacral regions [1-7]. It can grow exophytic above and below the dura of spinal cord...