Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as ...

Injury to the adult mammalian spinal cord leads to permanent loss of controlled neurological function. Endogenous repair mechanisms fail to reestablish functional synoptic connections. Moreover, neurological outcome usually gets worse in time, due to neurodestructive processes inherent to the adult spinal cord. Surgical repair strategies need to focus on replacing damaged/ lost nervous tissue, ...

Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as ...

Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as ...

Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as ...

Several experimental strategies have been employed to minimize tissue damage and to enhance axonal growth and regeneration after spinal cord injury. The transplantation of suitable cell types to provide an axonal growth substrate and the application of growth factors have been shown to augment morphological and sometimes functional recovery. In this review we discuss the use of neural stem cell...

In the rat, afew long descending motor tracts capable of carrying an impulse and causing apropagated impulse in the ipsilateral sciatic nerve will regenerate after complete spinal cord transection. In this experiment such regeneration was found in both treated and control animals. Orthograde axonal transport of tritiated proline injected into the motor cortex labels only the corticospinal tract...

Simultaneous suppression of glial scarring and a general enhancement of axonal outgrowth has now been accomplished in an adult rat model of spinal cord transection. Transplantation of a novel astrocyte cell type derived from glial-restricted precursors in vitro raise the eventual possibility of cellular therapy for spinal cord injury.

1 Paracelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, Austria 2 Paracelsus Medical University, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, Austria 3 University Cli...

Secondary injury in the spinal cord, which results in axonal degeneration, scar and cavity formation and cell death, occurs around the site of the initial trauma and is a primary cause for the lack of axonal regeneration observed after spinal cord injury (SCI). The immune response after SCI is under investigation as a potential mediator of secondary injury. Treatment of SCI with 810 nm light su...