نتایج جستجو برای: spinal cord hemisection
تعداد نتایج: 142427 فیلتر نتایج به سال:
Treatments for spinal cord injury may promote new spinal cord synapses. However, the potential for new synapses between descending somatomotor and spinal sympathetic neurons has not been investigated. We studied rats with intact spinal cords and rats after a chronic, bilateral, dorsal spinal hemisection. We identified sympathetically related spinal neurons by transynaptic, retrograde transport ...
Upregulation and activation of developmental axon guidance molecules, such as semaphorins and members of the Eph receptor tyrosine kinase family and their ligands, the ephrins, play a role in the inhibition of axonal regeneration following injury to the central nervous system. Previously we have demonstrated in a knockout model that axonal regeneration following spinal cord injury is promoted i...
An important role for sensory input in the motor performance of spinal cord injured (SCI) humans and animals has been established. For example, loading of the hind limbs during assisted locomotion on a treadmill improves the stepping ability of SCI patients and of complete spinal cord transected cats and rats. In our laboratories we are now using robotic devices to control and modulate the amou...
INTRODUCTION Neck pain is a common musculoskeletal problem that up to 70% of the world population will experience at some point in their lives. Intramedullary spinal cord metastasis is an exceedingly rare complication of malignancy that affects less than 1% of all patients with cancer. CASE REPORT We report a case of a 61-year-old man who presented to primary care clinic with 1-month history ...
The growth of injured axons in the adult mammalian CNS is limited after injury. Three myelin proteins, Nogo, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte myelin glycoprotein), bind to the Nogo-66 receptor (NgR) and inhibit axonal growth in vitro. Transgenic or viral blockade of NgR function allows axonal sprouting in vivo. Here, we administered the soluble function-blocking N...
We investigated local changes in BMP-2/4 expression in rat spinal cords 1 week following injury to study the damage effects of BMP-2/4 in spinal cord injury (SCI). Sprague Dawley rats (45, 4 months old) were randomized into three groups comprising 15 rats each: a SHAM group, an SCI without noggin group (SCIO), and an SCI with noggin group (SCID). The SCIO and SCID groups were subjected to spina...
The accurate measurement of behavioral compensation after CNS trauma, such as spinal cord injury, is important when assessing the functional effects of injury and treatment in animal models. We investigated the locomotor abilities of rats with unilateral thoracic or cervical spinal cord injuries using a locomotor rating (BBB) scale, reflex tests, and quantitative kinetic measurements. The BBB r...
OBJECT Stem cell therapy has been shown to have considerable therapeutic potential for spinal cord injuries (SCIs); however, most experiments in animals have been performed by injecting cells directly into the injured parenchyma. This invasive technique compromises the injured spinal cord, although it delivers cells into the hostile environment of the acutely injured cord. In this study, the au...
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