w The major difficulty in albino diagnosis is that although foveal hypoplasii seems a consistent feature, it is not uncommon for an albino to have normal fundus pigmentation, normal iris pigmentation and/or no nystagmus. Only a retina-ge.nicula-coni misprojection seems pathognomonic to albinism since all species of albino mammals share this feature. With appropriate stimulus and recording condi...

To assess whether chronic heroin abuse may generate vascular central nervous deficits, we studied the profile of vascular alterations in 17 heroin addicts (14 males mean age 31 years, range 23-39 years and 3 females mean age 33 years, range 30-35 years) before and, in one of them, 10 weeks after an ultra-rapid heroin detoxification. Using the functional technique of single-photon emission tomog...

Received 10/14/2002; accepted 10/29/2002. For correspondence or reprints contact: Michel De Maeseneer M.D., Ph.D., Department of Radiology, Free University Brussels, Laerbeeklaan 101, 1090 Jette, Brussels, Belgium. Tel: (32)2-4775320, Fax: (32)2-4775296, E-mail: [email protected] We present a 34-year-old man with pain at the level of the anterior chest wall. A lesion of the rib or rib car...

Ultrasonography (US), radiography of the kidneys, ureters and bladder (RKUB), intravenous urography (IVU) and especially non-enchanced CT are well established diagnostic modalities in screening patients with urolithiasis, while not always fully diagnostic especially when obstructive uropathy or calculous pyelonephritis are present . Diuretic renal scintigraphy (DRS) can determine obstruction, m...

Many cases of coeliac disease, a gastrointestinal autoimmune disorder caused by sensitivity to gluten, can remain in a subclinical stage or undiagnosed. In a significant proportion of cases (10-15%) gluten intolerance can be associated with central or peripheral nervous system and psychiatric disorders.A 38-year-old man was admitted as to our department an inpatient for worsening anxiety sympto...

The first investigation of the central-type benzodiazepine (BZ) receptor density before and following 2 months successful treatment with carbamazepine (CBZ) in a patient with temporal lobe epilepsy (TLE) using 123I-labelled Iomazenil (a specific lipophile central BZ receptor compound) and single photon emission tomography (SPET) is reported. First, a focal slowing of the EEG in the left tempora...

Assessment of left ventricular (LV) function in patients with myocardial infarction (MI) provide useful diagnostic and prognostic information. Up to date, single photon emission tomography (SPET), positron emission tomography (PET), multidetector computed tomographic angiography, echocardiography (EC) and magnetic resonance imaging (MRI), have been used to examine LV parameters. However, due to...

Defining the in vivo folding pathway of cellular RNAs is essential to understand how they reach their final native conformation. We here introduce a novel method, named Structural Probing of Elongating Transcripts (SPET-seq), that permits single-base resolution analysis of transcription intermediates' secondary structures on a transcriptome-wide scale, enabling base-resolution analysis of the R...

Tc-99m sestamibi has been reported to accumulate in several tissues with increased metabolism and particularly in solid tumors. Although the clinical utility of this radiopharmaceutical has been described in primary breast cancer and its axillary involvement, it has not been fully evaluated in local recurrence or distant metastasis. We illustrate the case of a post-mastectomy patient in whom Tc...

In a consecutive series of 7350 myocardial perfusion SPECT studies, 66 (0.9%) nonrevascularized patients with a normal resting ECG had normal scintigraphic findings with a positive ECG in the exercise test. We retrospectively analyzed 33 patients with coronary angiography, 26 of whom were women (P< .000). Twenty one of the 26 women (81%) and 1 of the 7 men (14%) had normal coronary angiographic...