BACKGROUND Fibroblast growth factor-23 (FGF-23), a novel marker of bone disease in chronic kidney disease (CKD) has been shown to correlate with vascular calcifications. We aimed to describe the effect of the calcium phosphate product (Ca*P) on FGF-23 concentrations in children and young adults without confounding cardiovascular disease. METHODS Pediatric and young adult patients with CKD sta...

Research shows potential effects of floods on intestinal infections. Baise, a city in Guangxi Province (China) had experienced several floods between 2004 and 2012 due to heavy and constant precipitation. This study aimed to examine the relationship between floods and the incidence of bacillary dysentery in Baise. A mixed generalized additive model and Spearman correlation were applied to analy...

An open problem for Distributed Information Retrieval is how to represent large document repositories (known as resources) efficiently. To facilitate resource selection, estimated descriptions of each resource are required, especially when faced with non-cooperative distributed environments[1]. Accurate and efficient Resource description estimation is required as this can have an affect on reso...

UNLABELLED The purpose of this study was to develop a method of registering (18)F-FDG PET with MR permeability images for investigating the correlation of (18)F-FDG uptake, permeability, and cerebral blood volume (CBV) in children with pediatric brain tumors and their relationship with outcome. METHODS Twenty-four children with brain tumors in a phase II study of bevacizumab and irinotecan un...

Correlation-based multidimensional scaling is proposed for reconstructing pairwise dissimilarity or score relationships in a Euclidean space. Pearson correlation between pairs of objects in source and target space can be directly maximized by gradient methods, while gradient optimization of Spearman rank correlation profits from a numerically soft formulation introduced in this work. Scale and ...

We report on the prediction accuracy of ligand-based (2D QSAR) and structure-based (MedusaDock) methods used both independently and in consensus for ranking the congeneric series of ligands binding to three protein targets (UK, ERK2, and CHK1) from the CSAR 2011 benchmark exercise. An ensemble of predictive QSAR models was developed using known binders of these three targets extracted from the ...

PURPOSE To evaluate the validity and reliability of the telephone-administered long IPAQ version. METHODS The questionnaire was administered by telephone to adults on days 1 and 6. On day 1, the same questionnaire was administered by face-to-face interview, and accelerometers were delivered to subjects. Reliability was measured by comparing data collected using the telephone questionnaire on ...

Pharmaceutical substances and their residues are increasingly present in the environment. Therefore, attempts at their removal are made by using different processes. Increasingly important among these processes are those modeled on natural phenomena which occur in wetland ecosystems, called technical scale constructed wetlands. Microbial degradation is an important process in these constructed ...

Rett syndrome (RTT) is a severe developmental-neurological disorder, characterized by profound and progressive loss of intellectual functioning, occurring after a period (of at least 6 months) of normal development with classic stereotype hand movements, gait ataxia, jerky truncal ataxia, deceleration of brain and body organ growth and cardiac dysautonomia. Pathogenesis of sympathetic overactiv...

PURPOSE To evaluate the magnitude of refractive astigmatism after congenital cataract surgery and to define its correlation with patient age. METHODS The authors retrospectively reviewed the charts of all pediatric patients who underwent congenital cataract extraction with intraocular lens (IOL) implantation through a 3.0-mm clear corneal incision from 1998 to 2003, and had no suture removal ...