The focus of this study is the development of a statistical modelling procedure for characterising intra-tumour heterogeneity, motivated by recent clinical literature indicating that a variety of tumours exhibit a considerable degree of genetic spatial variability. A formal spatial statistical model has been developed and used to characterise the structural heterogeneity of a number of supraten...

The focus of this study is the development of a statistical modelling procedure for characterising intra-tumour heterogeneity, motivated by recent clinical literature indicating that a variety of tumours exhibit a considerable degree of genetic spatial variability. A formal spatial statistical model has been developed and used to characterise the structural heterogeneity of a number of supraten...

The focus of this study is the development of a statistical modelling procedure for characterising intra-tumour heterogeneity, motivated by recent clinical literature indicating that a variety of tumours exhibit a considerable degree of genetic spatial variability. A formal spatial statistical model has been developed and used to characterise the structural heterogeneity of a number of supraten...

The time evolution of random variables with Lévy statistics has the ability to develop jumps, displaying very different behaviors from continuously fluctuating cases. Such patterns appear in an ever broadening range of examples including random lasers, non-Gaussian kinetics, or foraging strategies. The penalizing or reinforcing effect of the environment, however, has been little explored so far...

In this paper, we investigate some properties of a new type of 2D Hidden Markov Model, based on the notion of Dependency Tree. DT-HMMs avoid the complexity of regular 2D HMMs by changing the double horizontal and vertical spatial dependencies into a random uni-directional dependency, either horizontal or vertical. We explore various issues about the effect of this random choice. This type of pr...

We experimentally study spatial fluctuations of the local density of states (LDOS) inside three-dimensional random photonic media. The LDOS is probed at many positions inside random photonic media by measuring emission rates of a large number of individual fluorescent nanospheres. The emission rates are observed to fluctuate spatially, and the variance of the fluctuations increases with the sca...

Introduction: The present study investigated the role of the Basolateral Amygdala (BLA) N-methyl-D-aspartate  (NMDA) receptors in stress-induced spatial memory disturbance among the male Wistar rats. Methods: The male Wistar rats (Average weight =200 g) were cannulated bilaterally in the BLA, and entered the study (n=6-8) after one week. They received seven electro–foot-shock stress sessions o...

Introduction Absenteeism has been considered as a potential indicator for the early detection of infectious disease outbreaks in population, especially in primary schools. However, in practice this data are often characterized by an excess of zeros and spatial heterogeneity. In a project on integrated syndromic surveillance system (ISSC) in rural China(1), Random effect zero-inflated Poisson (R...