Macrocyclic peptides with multiple disulfide cross-linkages, such as those produced by plants and those found in nonhuman primates, as components of the innate immunity, hold great promise for molecular therapy because of their broad biological activities and high chemical, thermal, and enzymatic stability. However, for some, because of their intricate spatial arrangement and elaborate interstr...

The presented software provides a set of elaboration functions to investigate the diarthrodial joint kinematics (helical axes, instantaneous rotations, instantaneous displacements), bone anatomy (contact points, 2D bone sections, profile fittings) and ligament-tendon properties (elongations, orientations, fibre strain). Moreover, an user-friendly graphical interface allows the end user to manag...

The overall goals of this research are: 1. To define and characterize the variabilities and uncertainties in the components and linkages of the general physical-geo-acoustical system relevant to the support of naval operations. 2. To transfer quantitatively the spatial-temporal environmental variabilities and uncertainties through the interdisciplinary system, including coupled interactions, in...

Throughout the 1930s bank failures were highly clustered in time and space. This suggests that financial linkages between banks and/or systematic shocks that affected many banks simultaneously played important roles in depression era banking panics. This paper uses a Bayesian hazard rate model of bank suspensions with spatial and network effects to explore modes of contagion during the banking ...

This paper addresses the synthesis of a novel reactionless spatial 6-DOF parallel mechanism using four-bar linkages without any counter-rotations. The mechanism is first described and its kinematics is discussed. A numerical example of the reactionless 6-DOF mechanism is given in this paper and, with the help of the dynamic simulation software ADAMS, it is shown that the mechanism is reactionle...

this paper investigates the relationship between the lagos megacity and ota township, a small township onits periphery. the study examines linkages between and lagos in terms of growth, urban development as well as mobility. 553 questionnaires were administered to household heads across the 12 residential districts of ota township. survey was carried out by systematic random sampling. classifie...