A family with 24 males affected by an X-linked type of spastic paraplegia is reported. Twelve affected members were personally examined showing the pure form of the disease. Half of the affected males had many descendants, all normal. Linkage studies strongly suggest that this X-linked form of spastic paraplegia and Xg loci are not at a measurable distance on the X chromosome.

TO THE EDITOR: For the successful translation of basic research to humans, the adequacy of the animal model being studied is of crucial importance. With respect to the frequently occurring spastic syndrome, as a consequence of brain or spinal cord damage, the spastic rat tail is commonly applied as a model. Animal studies using this model focus on the mechanisms underlying increased neuronal ac...

UNLABELLED Previous studies have indicated that foetomaternal infection increases the risk of spastic cerebral palsy (CP) in term infants, whereas this association appears to be less evident in preterm infants. The aim of this study was to analyse infection-related risk factors for spastic CP in preterm infants. A population-based series of preterm infants with spastic CP, 91 very preterm (<32 ...

To assess whether spontaneous coronary artery spasm in patients with variant angina results from local coronary hyperreactivity to a generalized constrictor stimulus or from a stimulus generated only at the site of the hyperreactive segment, the behavior of spastic and nonspastic coronary segments was studied in six patients with variant angina in whom focal coronary spasm developed spontaneous...

BACKGROUND Selective dorsal rhizotomy (SDR) is often recommended for children with spastic paraparesis and cerebral palsy. SDR reduces spasticity in the lower extremities for these children with spastic paraplegia. However, SDR is infrequently recommended for adults with spasticity. Spastic diplegia in adult patients can be due to stroke, brain or spinal cord injury from trauma, infection, toxi...

how to cite this article: dalvand h, dehghan l, feizi a, hosseini sa, amirsalari s. iran j child neurol. 2013 autumn; 7(4):12-19. abstract objective the purpose of this study was to examine the impacts of hinged and solid anklefoot orthoses (afos) on standing and walking abilities in children with spastic diplegia. materials & methods in a quasi-experimental design, 30 children with spastic dip...