Hypoxia in the tumor microenvironment (TME) greatly limits tumor-killing therapeutic efficacy of sonodynamic therapy (SDT); this phenomenon is further exacerbated by increased glutathione (GSH) levels cancer cells. Simultaneously, starvation increasingly recognized nowadays as a promising clinical translation, but glucose oxidase (GOx)-based also limited lack oxygen tumor. Glycer-aldehyde-3-pho...

BACKGROUND Sonodynamic therapy (SDT) is a new approach for cancer treatment. Repair by reoxygenation induces cell damage in all treatment which uses photo- and sonosensitizers. In this study, the in vivo antitumor effect of dual-frequency sonication is investigated at low-level intensity and hematoporphyrin (Hp). It is used for the treatment of spontaneous breast adenocarcinoma of Balb/c mice w...

Photochemical internalization (PCI) is a technique that uses the photochemical properties of photodynamic therapy (PDT) for the enhanced delivery of endolysosomal-trapped macromolecules into the cell cytoplasm. The released agent can therefore exert its full biological activity, in contrast to being degraded by lysosomal hydrolases. Activation of photosensitizers via ultrasound (US), called son...

Sonodynamic Therapy (SDT) is a new anticancer strategy based on ultrasound (US) technique and derived from photodynamic therapy (PDT); SDT still, however, far clinical application. In order to move this forward bench bedside, investigations have been focused treatment selectivity between cancer cells normal cells. As result, the effects of porphyrin activation by (HT-29) (HDF 106-05) were studi...

Mn(III) porphyrins have great potential as Gd-free MRI contrast agents because both the cation and ligand interesting properties. The redox properties of Mn(III)-ion can be exploited for preparation reactive oxygen species therapy. Moreover, porphyrin allows these complexes to a high affinity tumor tissues. inherent ligands make systems attractive photothermal, photodynamic, sonodynamic therapi...