TV-1106 is a human serum albumin genetically fused to recombinant human growth hormone, designed to provide a long-acting alternative to daily growth hormone (GH) injections in patients with GH deficiency. This study investigated the pharmacokinetics, pharmacodynamics, and safety of single subcutaneous doses of TV-1106 (7.5, 15, 50, and 100 mg) in Japanese (n = 44) and caucasian (n = 44) health...

Levels of Lp(a), an atherogenic lipoprotein that circulates in human plasma, are increased by the administration of growth hormone (GH). Many of the physiological effects of GH are mediated through insulin-like growth factor-1 (IGF-1), but ironically, IGF-1 treatment of humans is associated with a fall in plasma Lp(a) levels. To glean insight into the mechanism responsible for the GH-associated...

BACKGROUND Recombinant human growth hormone (rhGH) can increase the growth rate in growth hormone deficient children (GHD). In this randomized clinical trial, we compared the efficacy and side effects of an Iranian brand; Samtropin with Norditropin. METHODS The GHD children were randomly treated either with standard dose of Samtropin or Norditropin rhGH for one year. Upstanding height, height...

• Blood growth hormone (GH) concentrations increase shortly after calving. • Greater blood GH coordinates nutrient partitioning; the process through which nutrients are preferentially targeted for milk production. Blood insulin and insulin-like growth factor (IGF)-I remain low when blood GH concentrations increase. • Blood GH concentrations are elevated in cows in negative energy balance. Blood...

Plasma growth hormone (GH) levels were measured during the first 2 hours of sleep without electroencephalogram monitoring and then after arginine infusion in 28 children investigated for short stature. Ten children considered GH deficient on clinical and biochemical grounds had concordantly low GH levels during sleep and after arginine stimulation. Of the 18 children without GH deficiency, 17 h...

We have studied the physiological and clinical relevance of measurements of serum total and free IGF-I and IGF-binding protein-3 (IGFBP-3) in 57 previously untreated patients with active acromegaly (32 males, 25 females; mean age 47 years) as compared with sex- and age-matched normal healthy controls. Serum total and free IGF-I, but not IGFBP-3, are suitable biochemical parameters for screening...

Placenta-derived hormones including growth hormone (GH) in humans contribute to maternal adaptation to pregnancy, and intermittent maternal GH administration increases foetal growth in several species. Both patterns and abundance of circulating GH are important for its activity, but their changes during pregnancy have only been reported in humans and rats. The aim of the present study was to ch...

In this study, dioscin was isolated from Dioscoreae Rhizoma (DR), which is the rhizome of Dioscorea batatas D(ECNE). that inhabits broad areas of Korea and Japan. To determine whether dioscin induced growth hormone (GH) release, we evaluated its induction effects on GH release both in vitro and in vivo. The 70% methanol extract of DR, and its n-hexane and n-BuOH fractions, induced rat GH (rGH) ...

The diurnal pattern of growth hormone (GH) serum levels depends on the frequency and amplitude of GH secretory events, the kinetics of GH infusion into and clearance from the circulation, and the feedback of GH on its secretion. We present a two-dimensional linear differential equation model based on these physiological principles to describe GH diurnal patterns. The model characterizes the ons...

Plasma GH profiles and IGF-I concentrations were determined in Large White intact male (LW-M), female (LW-F) and castrated male (LW-C) and in Meishan intact male (MS-M) pigs between 10 and 140 d of age. Mean GH levels slightly increased between 10 and 45 d of age in LW pigs, in connection with an alteration in the temporal distribution of GH peaks, whereas neither interpulse GH level nor maximu...