Recently, two small-molecule kinase inhibitors targeting epidermal growth factor receptor have proven effective in the treatment of non-small cell lung cancer. There are specific activating mutations within the tyrosine kinase domain of epidermal growth factor receptor related to the sensitivity of tyrosine kinase inhibitors. However, it is unknown whether rare mutations in the N-lobe (exons 18...

Somatic embryogenesis (SE) cloning techniques for Nordmann fir Christmas tree production have been pursued and refined in Denmark, three SE clonal trials with 201 clones from seeds of 27 trees seedlings bulk harvest Georgia, Caucasus, were established 2014 to 2015. This study was the first evaluate genetic performance these different sites. In addition, (zygotic) normal field compared this stud...

Successful efficient whole cauliflower plant regeneration via somatic embryogenesis from root derived callus tissue was achieved. The research confirmed for the first time the capability of mass production of cauliflower somatic embryos through the indirect pathway. The best callus induction and proliferation was on semi solid Murashige and Skoog (MS) medium supplemented with 2, 4-D at 0.15 mg ...

This study was designed to examine the effects of recombinant human growth hormone replacement on somatic growth and cognitive function in hypophysectomized (HYPOX) female Sprague-Dawley rats. Rats (5 per group) were randomized by weight to 3 experimental groups: group 1, administered 200 microg/kg of GH once daily for 9 days; group 2, administered 200 microg/kg of GH twice daily; and group 3, ...

With the spread of pollinosis caused by sugi (Japanese cedar, Cryptomeria japonica) pollen, use pollen-free somatic seedlings is expected in Japan. However, there a lack knowledge on relationship between abilities during embryogenesis, initial vitro growth traits, and subsequent seedlings. In present study, we provide first basic information embryo maturation efficiency, germination, plantlet c...

Variation in somatic growth rates is of great interest to biologists because of the relationship between growth and other fitness-determining traits, and it results from both genetic and environmentally induced variation (i.e. plasticity). Theoretical predictions suggest that mean somatic growth rates and the shape of the reaction norm for growth can be influenced by variation in predator-induc...

Although the Myc oncogene has long been known to play a role in many human cancers, the mechanisms that mediate its effects in both normal cells and cancer cells are not fully understood. We have initiated a genetic analysis of the Drosophila homolog of the Myc oncoprotein (dMyc), which is encoded by the dm locus. We carried out mosaic analysis to elucidate the functions of dMyc in the germline...

OBJECTIVE Children with sickle cell disease (SCD) exhibit poor somatic growth due to nutritional and metabolic effects, but potential relationships between growth and other areas of development are unclear. We examined whether growth is related to cognition and whether growth might be one marker of neurocognitive risk. METHODS Sixty-four children with SCD and eighty-one demographically simila...

In vitro propagation of Tilia platyphyllos Scop. has been achieved by axillary shoot proliferation and somatic embryogenesis. The influence of tree age, explant source, genotype, and phytohormones on micropropagation of juvenile and mature trees of Tilia platyphyllos has been investigated. Nodal segments and shoot tips were used as initial explants for axillary shoot proliferation. Low concentr...

Somatic embryogenesis is an important biotechnological tool that demonstrates significant benefits when applied to forest tree species; clonal propagation, cryostorage of valuable germoplasm and genetic transformation are among the most promising of its applications. In this chapter, the state of the art of somatic embryogenesis in chestnut (an important economical tree species of the genus Cas...