Suzuki, T. (Children's Hospital, Buffalo, N.Y.), E. A. Gorzynski, and E. Neter. Separation by ethanol of common and somatic antigens of Enterobacteriaceae. J. Bacteriol. 88:1240-1243. 1964.-Ethanol in a concentration of 85% permits separation from crude culture supernatant fluids of the common enterobacterial antigen and the O antigen, the former being ethanol-soluble, the latter being ethanol-...

In chronic lymphocytic leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic hypermutation identifies 2 prognostic subsets, mutated and unmutated. Investigators have postulated that unmutated and mutated CLL arises from malignant transformation of pre- and post-germinal center (GC) B cells, respectively. Alternatively, unmutated cases may arise from B cells stimula...

Inbred 129/Sv mice were resistant to inoculation of teratocarcinoma cells when preimmunized with (129teratocarcinoma x C3H L-cell) somatic cell hybrids ob tained by fusion with UV-inactivated Sendai virus. Re sistance of DBA/2 mice to the highly malignant L1210 leukemia was also obtained by the use of (L1210 x C3H L-cell) hybrids. That this resistance was specific was sug gested by regular take...

Indirect plate enzyme-linked immunosorbent assay was standardized and evaluated for its effectivenessin immunodiagnosis of haemonchosis in experimental and clinical cases in sheep by using somatic wholeadult antigen of H. contortus. Plate ELISA was standardized using 5 μg/well antigen concentration with1:100 and 1:1000 of sera and conjugate dilution. Indirect plate ELISA was able to demonstrate...

Because diagnosis of strongyloidiasis by stool examination is unreliable and because of the potential for serious disease in Strongyloides infections, there is need for improved diagnostic aids to facilitate recognition and treatment of this parasitic infection. Serologic testing, when available, requires antigen preparation from infected primates or dogs that can be difficult to maintain. Seve...

Background Adoptive transfer of tumor-infiltrating lymphocytes (TIL) can mediate complete regression of metastatic cervical cancer, but the immunological landscape of the anti-tumor T cell responses in these patients is not fully understood. Reactivity against the human papillomavirus (HPV)-derived antigens may contribute to the clinical responses, but whether other immunogenic tumor antigens a...

Abstract There is increasing interest in how immune cells the meninges, membranes that surround brain and spinal cord, contribute to homeostasis disease central nervous system. The outer layer of dura mater, contains both innate adaptive functions as a site for B cell development. In this study, we identified previously undescribed lymphoid structures surrounding fenestrated venous plexi mater....

Among features of real immune responses which occur when antigens invade a body, there are two remarkable features. One is that the amount of antibodies produced in the secondary invasion by the same antigens is more than 10 times larger than that in the primary invasion. The other is that more effective antibodies which can neutralize the antigens more quickly are produced by somatic hypermuta...

As prostate cancer is the second leading cause of death after lung cancer, several diagnostic strategies have been introduced in recent years. Among these prostate-specific antigens, it widely recognized that this simplest and most common clinical endpoint - genetic instability part oncogenic process. Gene mutations involved DNA repair mechanisms may promote participate oncogenesis metastatic p...

Johnson, E. M. (Walter Reed Army Institute of Research, Washington, D.C.), Barbara Krauskopf, and L. S. Baron. Genetic mapping of Vi and somatic antigenic determinants in Salmonella. J. Bacteriol. 90:302-308. 1965.-The Vi antigen and somatic antigen 9 were transferred to Salmonella typhimurium recipients by mating with S. typhosa Hfr TD-7, and the genetic determinants of these antigens were loc...