During pandemics and global crises, drug shortages become critical as a result of increased demand, in personnel lockdown restrictions that disrupt the supply chain. The pharmaceutical industry is therefore moving towards continuous manufacturing instead conventional batch involving numerous steps, normally occur at different sites. In order to validate use large-scale industrial processes, fea...

Whenever a drug's success depends on its ability to disperse evenly in the liquid phase, solubility is critical factor. Most active pharmacological compounds, other hand, are poorly soluble water. The of medications one most difficult parts formulation creation. Due lack water solubility, ingredients left out final medications, preventing them from reaching their full therapeutic potential. poo...

Artemether-lumefantrine is World Health Organization approved fixed dose combination for malaria treatment. These drugs have poor bioavailability due to low solubility and dissolution. The objective of this work was improve by increasing dissolution both drugs. In solid dispersion using hydrophilic carriers like polyvinylpyrrolidone K-30, Soluplus Lutrol F68 solvent evaporation technique prepar...

Abstract: Background: Azilsartan medoxomil (AZL) is an orally active nonpeptide angiotensin II receptor antagonist with less water solubility and oral bioavailability. Objectives: Increase the dissolving rate of AZL. Materials Methods: For formulation we used a probe sonication approach to create nanocrystals. The impacts independent factors such as % polymer concentration (X1) duration (X2 min...