نتایج جستجو برای: soluble cd30

تعداد نتایج: 90963  

2018
Stefan Schönberger Cornelius van Beekum Barbara Götz Daniel Nettersheim Hubert Schorle Dominik T Schneider Anna Casati Rogerio B Craveiro Gabriele Calaminus Dagmar Dilloo

Prognosis in patients suffering from high-risk, refractory and relapsed germ cell tumours (GCT) often comprising of CD30-positive embryonal carcinoma (EC) components remains poor. Thus, novel treatment strategies are warranted. The antibody-drug conjugate (ADC) brentuximab vedotin delivers the potent antimitotic drug monomethyl auristatin E (MMAE) to CD30-expressing tumour cells. After CD30 bin...

Journal: :Blood 2013
Shimin Hu Zijun Y Xu-Monette Aarthi Balasubramanyam Ganiraju C Manyam Carlo Visco Alexander Tzankov Wei-min Liu Roberto N Miranda Li Zhang Santiago Montes-Moreno Karen Dybkær April Chiu Attilio Orazi Youli Zu Govind Bhagat Kristy L Richards Eric D Hsi William W L Choi J Han van Krieken Qin Huang Jooryung Huh Weiyun Ai Maurilio Ponzoni Andrés J M Ferreri Xiaoying Zhao Jane N Winter Mingzhi Zhang Ling Li Michael B Møller Miguel A Piris Yong Li Ronald S Go Lin Wu L Jeffrey Medeiros Ken H Young

CD30, originally identified as a cell-surface marker of Reed-Sternberg and Hodgkin cells of classical Hodgkin lymphoma, is also expressed by several types of non-Hodgkin lymphoma, including a subset of diffuse large B-cell lymphoma (DLBCL). However, the prognostic and biological importance of CD30 expression in DLBCL is unknown. Here we report that CD30 expression is a favorable prognostic fact...

2015
Xiaoxiao Hao Xiaolei Wei Fen Huang Yongqiang Wei Hong Zeng Linwei Xu Qinjun Zhou Ru Feng

The prognostic value of CD30 expression in diffuse large B-cell lymphoma (DLBCL)remains controversial. Herein, we performed this retrospective study to investigate the clinical and prognostic significance of CD30 expression in patients with DLBCL.Among all the 146 patients, the expression of CD30 was observed in 23 cases (15.7%).The DLBCL patients with CD30 expression showed more likely to pres...

Journal: :Molecular cancer therapeutics 2015
Snehal Dabir Adam Kresak Michael Yang Pingfu Fu Gary Wildey Afshin Dowlati

CD30 is a cytokine receptor belonging to the TNF superfamily (TNFRSF8) that acts as a regulator of apoptosis. The presence of CD30 antigen is important in the diagnosis of Hodgkin disease and anaplastic large cell lymphoma. There have been sporadic reports of CD30 expression in nonlymphoid tumors, including malignant mesothelioma. Given the remarkable success of brentuximab vedotin, an antibody...

2018
Rong Wang Liang Li Shenghua Zhang Yi Li Xiaofei Wang Qingfang Miao Yongsu Zhen

CD30 is a 120-kDa type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. Overexpression of CD30 has been reported in Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL). CD30-targeted treatment with antibody-drug conjugates (ADCs) can lead to promising clinical benefit. Lidamycin (LDM), consisting of an apoprotein LDP and an active enediyne ...

2012
Sarah L. Buchan Aymen Al-Shamkhani

The TNF-receptor superfamily member CD30 is expressed on normal and malignant lymphocytes, including anaplastic large cell lymphoma (ALCL) cells. CD30 transmits multiple effects, including activation of NF-κB signaling, cell proliferation, growth arrest and apoptosis. How CD30 generates these pleiotropic effects is currently unknown. Herein we describe ALCL cells expressing truncated forms of t...

ژورنال: :مجله دانشگاه علوم پزشکی بابل 0
علیرضا رفیعی، ، ar rafiei, آدرس: ساری، گروه میکروبشناسی و ایمونولوژی مرکز تحقیقات بیولوژی سلولی و مولکولی دانشگاه علوم پزشکی مازندران، e-mail: [email protected] محمدرضا حسنجانی روشن mr hasanjani roushan زهرا حسینی خواه، z hoseini khah ابوالقاسم ، عجمی a . ajami ضیاء عروجی z orouji

سابقه و هدف: بروسلوز یا تب مالت یکی از بیماریهای عفونی که به لحاظ قابلیت انتقال بین دام و انسان از اهمیت بسزایی برخوردار است. ایمنی در این بیماری با تکامل پاسخهای سلولهای t کمکی نوع 1 (th-1) مرتبط بوده در حالیکه پاسخهای th-2 موجب وخامت بیماری می شوند. سلولهای th-1 و th-2 علاوه بر الگوی سیتوکاینی متفاوت، از نظر بروز مولکولهای سطحی نیز متفاوتند. بطوریکه مولکولهای cd26 و cd30 بترتیب در سطح سلولهای...

Journal: :iranian journal of immunology 0
behrouz gharesi-fard infertility research center leila jafarzadeh department of immunology jaleh zolghadri infertility research center hossein haghbin infertility research center

background: normal pregnancy is thought to be dependent on th2 deviation, while recurrent pregnancy loss (rpl) and pre-eclampsia (pe) appear to be biased toward the th1 immune response. it is believed that the soluble form of cd30 (scd30) is an index of th2 immune response or modulator of th1/th2 responses. objective: the aim of this study was determination of the scd30 level in rpl and pe pati...

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