Sistem limfatik saat ini telah banyak digunakan sebagai jalur penghantaran obat terutama pada terapi antikanker, antivirus, dan imunologi. Jalur juga terbukti memiliki keunggulan yang dapat memberikan efek lebih baik. Akan tetapi, sediaan farmasi untuk obat-obatan bertarget di kini termasuk Biopharmaceutics Classification System (BCS) kategori II, yaitu dengan kelarutan rendah permeabilitas Hal...

Introducing hollow structures into metallic nanoparticles has become a promising route to improve their catalytic performances. A fundamental understanding of thermal stability of these novel nanostructures is of significance for their syntheses and applications. In this article, molecular dynamics simulations have been employed to offer insights into the thermodynamic evolution of hollow bimet...

Berberine is an isoquinoline alkaloid possesses multitude of biological effects. However, quaternary amine cation berberine causes poor water solubility, resulting in low bioavailability which limits its pharmacological purpose. The aim this study was to prepare and optimize loaded solid lipid nanoparticle evaluate pharmacokinetic antihyperlipidemic activity. nanoparticles were prepared by solv...

Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, prolong the circulation time of various drugs. SLNs applied in oral, parenteral, transdermal, intranasal, ocular, pulmonary drug delivery different drugs, with enhanced safety, bioavailability, overall th...

Pancreatic cancer is the fourth largest cause of cancer deaths in the Unites States and the prognosis is grim with <5% survival chances upon diagnosis. The objective of this study was to assess the combined chemopreventive effect of solid lipid nanoparticle (SLN) encapsulated drugs aspirin (ASP), curcumin (CUR) and free sulforaphane (SFN) for the chemoprevention of pancreatic cancer. Experiment...

PURPOSE Histone modification has emerged as a promising approach to cancer therapy. The short-chain fatty acid, butyric acid, a histone deacetylase (HD) inhibitor, has shown anticancer activity. Butyrate transcriptional activation is indeed able to withdraw cancer cells from the cell cycle, leading to programmed cell death. Since butyrate's clinical use is hampered by unfavorable pharmacokineti...