نتایج جستجو برای: sn38
تعداد نتایج: 174 فیلتر نتایج به سال:
The 121 family of transcription factors, in partnership with DP pro teins, is thought to regulate transcription of genes that encode protein products that are required for DNA synthesis, which include important cancer chemotherapeutic targets such as thymidylate synthase and dihydrofolate reducÃ-ase.This study was conducted to investigate the effects of overexpression of human E2F-1 cDNA on Che...
We previously found that slowly internalizing antibodies conjugated with SN-38 could be used successfully when prepared with a linker that allows approximately 50% of the IgG-bound SN-38 to dissociate in serum every 24 hours. In this study, the efficacy of SN-38 conjugates prepared with epratuzumab (rapidly internalizing) and veltuzumab (slowly internalizing), humanized anti-CD22 and anti-CD20 ...
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