Approximately 40 % of newly discovered chemical entities have low solubility and possess bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) recently become very popular because their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying (SEDDS) are one type LBDDS employed for the incorporation hydrophobic drugs. SED...

It has been estimated that nearly 35-40 % of drugs suffer from poor aqueous solubility and it affects the absorption of drug from gastrointestinal tract that leads to high inter and intra subject variability, poor oral bioavailability, increase in dose, reduction in therapeutic efficiency and finally failure in formulation development. Various formulation strategies like micronization, solubili...

Sistem limfatik saat ini telah banyak digunakan sebagai jalur penghantaran obat terutama pada terapi antikanker, antivirus, dan imunologi. Jalur juga terbukti memiliki keunggulan yang dapat memberikan efek lebih baik. Akan tetapi, sediaan farmasi untuk obat-obatan bertarget di kini termasuk Biopharmaceutics Classification System (BCS) kategori II, yaitu dengan kelarutan rendah permeabilitas Hal...