We investigated the effects of rikkunshito, in combination with a proton pump inhibitor, on symptoms and quality of life in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. The subjects were 47 patients with gastroesophageal reflux disease with residual symptoms such as heartburn following 8 weeks of proton pump inhibitor therapy. We administered these subjects ri...

Abstract Introduction Hypoglossal nerve stimulation (HNS) for the treatment of obstructive sleep apnea (OSA) in patients who have failed positive airway pressure (PAP) therapy one reason or other is now standard care. Once device implanted and activated, voltage to stimulate has be titrated over time, ultimately leading an HNS titration study. There are 4 possible electrode configurations diffe...

The ice breaker and research vessel Polarstern, run by the Alfred Wegener Institute (AWI) on a busy schedule making the most of the summer season at each pole, is often involved in good causes, such as collecting data concerning the impact of climate change (see Curr. Biol. (2008) 18, R181). In January, however, she sailed straight into a row in which several NGOs and the German ministry of the...

The majority of individuals appear to have insight into their own sleepiness, but there is some evidence that this does not hold true for all, for example treated patients with obstructive sleep apnoea. Identification of sleep-related symptoms may help drivers determine their sleepiness, eye symptoms in particular show promise. Sixteen participants completed four motorway drives on two separate...

Objective. Obesity and obstructive sleep apnea (OSA) are closely interconnected conditions both leading to high cardiovascular risk. Inactivity is frequent and physical activity programs remain difficult in these patients. We investigated the acute feasibility of two neuromuscular electrical stimulation (NMES) modalities in extremely inactive obese patients with OSA. Design. A randomized cross-...

BACKGROUND Minority women, especially black and Hispanic women, have higher rates of coronary heart disease and resulting disability and death than do white women. A lack of knowledge of minority women's symptoms of coronary heart disease may contribute to these disparities. OBJECTIVE To compare black, Hispanic, and white women's prodromal and acute symptoms of myocardial infarction. METHOD...

The aim of this study was the evaluation of the discomfort level during the utilization of non oclusal intraoral appliance during sleep in patients with muscular temporomandibular dysfunction; time of acceptance; and the effectiveness of non oclusal intraoral appliance related to the relief of pain symptoms. We evaluated 30 patients from Orofacial Pain and Temporomandibular Dysfunction Clinic (...

The sleep loss (SL) are one of the important diseases that endanger health aging individuals. This study evaluated SL in individuals, and explored relationship between age organic changes affect brain sleep. causes individuals its harmful effects on them have been outlined. To enable choosing a suitable way to better, we also reviewed advantages disadvantages existing modulation based lifestyle...