The skin is a complex immunological niche providing immunity to invading pathogens while simultaneously maintaining tolerance to innocuous environmental antigens. Consistent with this complex response, the skin is resident to both immunosuppressive and effector cell populations whose activities are tightly regulated. While NKT cells can activate immune responses in the skin, this review will hi...

Long-term peritoneal dialysis was carried out on 38 patients awaiting human cadaveric renal transplantation. Fifty-eight per cent of patients developed infection before transplantation and 41% of those requiring dialysis after transplantation became infected. Infection did not usually occur before the third day of dialysis and 26% of patients developed their first episode of infection in the fi...

BACKGROUND Cancers occurring following solid organ transplantation are a rapidly growing public health concern. Defining the extent of the problem has been limited by surveillance systems with incomplete registration of cases and the paucity of reliable national incidence data. OBJECTIVES To determine the incidence of all cancers following renal transplantation and to make a detailed examinat...

Stem cell gene therapy followed by transplantation into damaged regions of the skin has been successfully used to treat genetic skin blistering disorder. Usually, many stem cells are virally transduced to obtain a sufficient number of genetically corrected cells required for successful transplantation, as genetic insertion in every stem cell cannot be precisely defined. In this issue of EMBO Mo...

De-novo malignancy is a serious posttransplant complication. While the incidence of Kaposi sarcoma (KS) is low, the time for its diagnosis is early after renal transplantation. Typically, it can be identified because of the classical skin lesion. We herein report an unusual case of rapid progressive KS without skin lesions in a 52-year-old patient leading to death within 8 months after kidney t...

GVHD: graft-versus-host-disease INTRODUCTION Acute graft-versus-host disease (GVHD) is the major complication of hematopoietic cell transplantation and affects multiple organs and systems, most commonly the skin. We report a case of acute GVHD localized to a tattoo in a patient with a history of allogeneic hematopoietic cell transplantation and describe typical and atypical cutaneous findings i...

Early repair of skin injury and maximal restoration of the function and appearance have become important targets of clinical treatment. In the present study, we observed the healing process of skin defects in nude mice and structural characteristics of the new skin after transplantation of isolated and cultured adipose derived mesenchymal stem cells (ADMSCs) onto the human acellular amniotic me...

Whether the impact of skin biological age on cytokine expression is a result of this tissue's proliferation potential or not is an important issue in dermatology. We investigated these questions by monitoring cytokine marker mRNA expression from human skin samples from healthy groups of individuals. The skin samples studied represented three age groups: fetal (17-21 weeks), young (18-35 years) ...

Tattoo removal from the forearm often requires excision and split skin grafting. The authors propose the use of a bloodless field to facilitate accurate dermal peeling, to ensure complete removal of the pigment, and to reduce operative time.