Background: Scabies is a common skin disease and a public health problem. The topical antiscabietics have a poor compliance. The aim of this study was to compare the efficacy of oral Ivermectin with topical Lindane solution in the treatment of scabies. Methods: This was a prospective comparative open study. Fifty seven patients were randomized in two groups. One group (32 patients) received 200...

Tacrolimus ointment is an agent approved for the treatment of atopic dermatitis; however, tacrolimus has been expected also as one of the promising therapeutic strategies for other T-cell mediated inflammatory skin disorders. Recent progress have demonstrated that topical tacrolimus shows beneficial effects for psoriasis depending on sites. In particular, facial, intertriginous, and genital pso...

Topical 5-fluorouracil (5-FU) is approved for the treatment of superficial basal cell carcinoma and actinic keratosis. However, 5-FU suffers from poor skin permeation. Microneedles have been successfully applied to improve the skin permeability of small and large molecules, and even nanoparticles, by creating micron-sized pores in the stratum corneum layer of the skin. In this report, the feasi...

Ablative fractional lasers (AFXL) are increasingly used to treat dermatological disorders and to facilitate laser-assisted topical drug delivery. In this thesis, laser-tissue interactions generated by stacked pulses with a miniaturized low-power 2,940 nm AFXL were characterized (study I). Knowledge of the correlation between laser parameters and tissue effects was used to deliver methotrexate (...

background and objective: angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. this study aims to investigate...

In this review the controversy regarding the association between topical pimecrolimus and tacrolimus and the development of tumors is unfolded. After reviewing the literature we conclude that, currently, there is no scientific evidence of an increased incidence of skin cancer, lymphomas or systemic immunosuppression in those patients that use or have used topical calcineurin inhibitors. Publish...

Skin infections are a common reason for patients to seek attention from dermatologists. The most common bacteria found in skin and soft tissue infections (SSTI) include the gram-positive organisms Staphylococcus aureus (55.2%), hemolytic Streptococci (5.0%), and Coagulasenegative Staphylococci (4.9%). Most of these bacteria causing SSTI have become resistant to the leading topical antimicrobial...

Cosmetic acceptability and primary skin irritation are the two main parameters for assessing the suitability of any topical formulation meant for protection against the painful bites of mosquitoes. In the present study four newer analogs of N,N-diethyl-2-phenylacetamide (DEPA), were synthesized and formulated for topical application as insect repellent. They were assessed for their irritant beh...

Acne vulgaris is a skin condition characterized by an obstruction or inflammation of the oil glands, present on skin's surface, which are collectively termed as pilosebaceous units. The face, back, and upper chest have greater number sebaceous follicles. Topical, systemic, combination therapy can be used to treat acne, while mild moderate acne generally treated with topical therapy. Topical has...

BACKGROUND Propionibacterium acnes infection is a significant problem after shoulder surgery. Residual P. acnes is found on the skin up to 29% of the time immediately after surgical skin preparation and in 70% of dermal biopsy specimens. These residual bacteria may be a source for infection. Identifying more ideal skin preparation may help reduce the risk of infection. The purpose of this study...