The purpose of this study is to investigate associations between allelic variations of ABCG2 and ABCB1 with skin toxicity, diarrhea, liver injury and interstitial lung disease (ILD) in gefitinib-treated patients. A prospective clinical study of 83 Japanese patients with non-small-cell lung cancer was performed. Polymorphic loci in ABCG2 and ABCB1 were genotyped, and their effects on gefitinib t...

Skin rash is a major side effect of erlotinib, an inhibitor of the epidermal growth factor receptor widely used in cancer treatment and clinical trials.This study aims to evaluate the risk of skin toxicity with erlotinib through a systematic review and meta-analysis of randomized controlled clinical trials (RCTs). Eligible studies included prospective RCTs in which erlotinib was compared with c...

History: A seven-month-old, developmentally normal girl – born at term with birth weight of 2.5 kg to a nonconsanguineously married couple – presented with fever and rash for 11⁄2 months. The illness started with generalized erythematous, maculopapular rash involving the flexural areas, scalp and trunk, along with intermittent fever. The rash subsided over 15 days leaving behind a dry, scaly sk...

Gemcitabine treatment is commonly associated with skin rash, with a reported incidence of 7%–30% [1–3]; however, there exists only one prior report describing the management of gemcitabine-associated rash in the English-language literature [1]. When an extensive skin rash develops, both the patient and physician may experience anxiety about continuing gemcitabine treatment. For patients with a ...

Y N Wear sunscreen daily on face/neck? Y N elsewhere?_______________ Y N when out in sun for longer time Y N Skin Cancer (type(s): _____________________ > Location on body: ______________________________________________ Y N Dysplastic/Abnormal Moles (biopsy-proven) Y N Psoriasis Y N Tanning bed use: # _________ Y N Eczema Y N Bad Sunburns: lifetime # _______ Y N Acne Y N Blistering sunburns # _...

A 42-year-old asplenic woman was evaluated for a 2-week history of intermittent high-grade fevers and pleuritic chest pain and skin rash (figure 1). A CTscan of the chest showed multiple small nodules on both lungs (figure 2). Fungal serological studies were negative. A skin biopsy revealed palisading dermal granulomatous inflammation with focal vascular destruction and was negative for any org...

A 26-year-old HIV-infected man presented with fever and disseminated maculopapular rash not involving his palms and soles. He had started antiretroviral therapy (ART) with an abacavir-based regimen three days prior. Although he tested negative for HLA-B*5701, the antiretrovirals were suspected to be the offending agent associated with the drug eruption. Within several days after discontinuing t...

A 43-year-old male patient was diagnosed with chronic myelogenous leukemia (CML), and hydroxyurea treatment was begun 3 months before consultation. Physical examination revealed the spleen 2 cm below the costal margin. The Philadelphia chromosome was positive. After hydroxyurea treatment, imatinib (Gleevec) was started. On the 15th day of imatinib treatment, the patient was admitted because of ...

1754 Effects of dopaminergic treatment on striatal dopamine turnover in de novo Parkinson disease A. Storch, M. Wolz, B. Beuthien-Baumann, M. Löhle, B. Herting, U. Schwanebeck, L. Oehme, J. van den Hoff, M. Perick, X. Grählert, J. Kotzerke, and H. Reichmann 1762 Targeted exome sequencing of suspected mitochondrial disorders D.S. Lieber, S.E. Calvo, K. Shanahan, N.G. Slate, S. Liu, S.G. Hershman...