findings into 3 groups. The first, nonspecific cutaneous signs and disorders (Table), has already been reported in association with SM exposure as late skin findings. However, owing to lack of a control group in the present descriptive study, and also the multifactorial causes of these disorders, correlation of them with exposure to SM could not be confirmed. Nonetheless, the higher incidence c...

book, and he has produced a valuable volume on neoplasms of the skin. Although consideration of malignant conditions occupy the greater part of this volume benign neoplasms also receive their due amount of attention. The book is copiously illustrated by excellent photographs and on the whole is clearly written, but we are sorry to see that the author talks of ' tubercular' skin lesions, when re...

Epidermolysis bullosa simplex (EBS) is a heritable skin disorder characterized by skin fragility and blistering. While its most severe variant, dystrophic epidermolysis bullosa (DEB) is associated with squamous cell carcinoma (SCC), the development of extracutaneous neoplasms in EBS is extremely rare. We report a novel case of supratentorial primitive neuroectodermal tumor (sPNET) in a 7-year m...

Of 1,486,984 new cancers registered in the Czech Cancer Registry in 1976-2005, 290,312 (19.5%) were multiple malignant neoplasms (MMNs), of which there were 65,292 primary and 89,796 subsequent cases in men and 59,970 primary and 75,254 subsequent cases in women. The duplicities were higher in women, and the triplicities and others (3-6 MMNs) were higher in men. The most frequent diagnoses were...

Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour. Furthermore, many eccrine/apocrine lesions coexist within hamartomas or within lesions with composite/mixed differentiation. In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been descri...

Skin cancer is the most common neoplasm in Brazil. Melanoma accounts for 4% of these neoplasms. Although childhood melanoma is rare, there is evidence that its incidence is increasing, placing it among the most important public health problems for the future. This work sought to conduct a retrospective review of cases of suspected melanocytic skin lesions in children, their diagnosis and manage...

Lymphoepithelioma-like carcinoma of the skin (LELCS) is a very rare cutaneous neoplasm with limited metastatic potential. It presents distinctive histopathologic features similar to undifferentiated nasopharyngeal carcinoma and clinical similarities with other skin neoplasms. We present the first case of LELCS in Polish patients. A 72-year-old woman presented with a 12 months' history of painle...

Tissue-resident memory T (TRM) cells have emerged as key players and potential immunotherapeutic targets in antitumor immunity. However, the study of TRM within TME has been hampered by a lack adequate tumor models. Cell lines injected subcutaneously do not contain same biological cues tumors arising from dermis epidermis, while most other models known tumor-specific antigen to track immune res...