Necrotising fasciitis is a rare but potentially lethal condition, often requiring extensive soft tissue debridement and complex reconstructive surgery. The disease has been noted to complicate Caesarian section wounds, and our department has recently managed three such patients. They all required extensive abdominal wall debridements which would traditionally be closed initially by split skin g...

 Lower extremity ulcers affect 8%-10% of individuals with sickle cell disease. The pathogenesis of this condition is poorly understood, and a good option for the long-term management of these lesions does not exist. Skin grafting and local wound care remain the mainstay of treatment; however, even short-term success often leads to long-term failure, as the wound might once again breakdown...

Scrotal surgery encompasses a wide-variety of surgical techniques for an even wider variety of indications. In this manuscript, we review our indications, techniques, and pit-falls for various reconstructive scrotal surgeries as-well-as surgical tips for placement of testicular prostheses. Penoscrotal webbing (PSW) is an abnormal, often-problematic distal insertion of scrotal skin onto the vent...

The effect of 4-nitroquinoline 1-oxide on the cell-mediated immune response was tested in C57BL/6 female mice. The carcinogen was administered s.c. either 30 days before or just prior to grafting the female recipients with C57BL/6 male skin. Skin graft survival times were noticeably prolonged in mice that received the carcinogen 30 days before grafting. Administration of 4-nitroquinoline 1-oxid...

The effect of 4-nitroquinoline 1-oxide on the cell-mediated immune response was tested in C57BL/6 female mice. The carcinogen was administered s.c. either 30 days before or just prior to grafting the female recipients with C57BL/6 male skin. Skin graft survival times were noticeably prolonged in mice that received the carcinogen 30 days before grafting. Administration of 4-nitroquinoline 1-oxid...

BACKGROUND The shortage of autologous skin sources not only adds difficulty to the repair of extremely large-area deep burn wounds but affects the healing quality. The aim of the present study is to explore an ideal method for repairing large-areas burn wounds with low scar formation. METHODS Between 2002 and 2014, we used grafting of small auto- and cryopreserved allo-skin to repair large-ar...

The almost forgotten method of intermingled skin grafting of allogeneic material with small autogeneic islets, once developed in the People's Republic of China, proves the feasibility of permanent healing of even extensive burn wounds, at low cost, and therefore an effective treatment possibility in poorer countries, as well as under conditions of a burn disaster. Intermingled skin grafting obt...

Cultured epidermal keratinocytes provide an abundant supply of biologic material for wound treatment. Because restoration of barrier function is a definitive criterion for efficacy of wound closure and depends on the lipids present in the epidermis, we analyzed lipid composition of the epidermis in cultured skin substitutes in vitro and after grafting to athymic mice. The cultured skin substitu...