Ectodermal dysplasia (ED) syndrome comprises a large, heterogeneous group of inherited disorders that are defined by primary defects in the development of 2 or more tissues derived from the embryonic ectoderm. The tissues primarily involved are the skin and its appendages (including hair follicles, eccrine glands, sebaceous glands, nails) and teeth. The clinical features include sparse hair, ab...

The evolution of the skin barrier and appendages were major steps in terrestrial vertebrates. Hair keratins are main components mammalian hair, but homologs these proteins also expressed claws reptiles, suggesting that hair have evolved from claw a hairless ancestor. Here, we tested hypothesis keratin their association with evolutionarily conserved even amphibians. We determined proteomes soft ...

The epidermis and its related appendages such as the hair follicle constitute the epithelial compartment of the skin. The exact location and distribution of the keratinocyte colony-forming cells within the epidermis or its appendages are unknown. We report that in the rat vibrissa, keratinocyte colony-forming cells are highly clustered in the bulge-containing region. Approximately 95% of the to...

Kocaoğlu C, Kocaoğlu Ç, Akkoyun İ, Karaniş İE. A case report with sacral appendage: Is it accessory penis or human tail? Turk J Pediatr 2017; 59: 335-337. Lumbo-sacro-coccygeal appendages are very rare congenital anomalies. It is difficult to say that they are a evolutionary inheritance (tail) from our ancestors or an anomaly (pseudotail) occuring during embrional development. If it is a true t...

The purpose of this work is to evaluate local power and electric field distributions inside high-resolution 3D anatomical CAD models cutaneous appendages at 60 GHz upcoming for 5G/6G. microscale resolution nerves, lymphatics, pilosebaceous unit, microvasculature, eccrine sweat glands, Meissner corpuscle Pacinian were designed based on morphometric data microscopic images. Maxwell’s Hanai’s mixt...

Skin appendage formation represents a process of regulated new growth. Bromodeoxyuridine labeling of developing chicken skin demonstrated the presence of localized growth zones, which first promote appendage formation and then move within each appendage to produce specific shapes. Initially, cells proliferate all over the presumptive skin. During the placode stage they are organized to form per...

Objective: To construct a burn model of early and midterm human Foetal Skin (hFS) in vitro, to observe its morphological and histological changes after transplantation, and to examine the expression of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs), and further to analyse their roles in foetal wound healing preliminarily. Methods: hFS harvested from aborted...

Abstract Camouflage is a widespread strategy to increase survival. The cryptic plumage colouration of precocial chicks improves camouflage often through disruptive colouration. Here, we examine whether and how fringed neoptile feathers conceal the outline chicks. We first conducted digital experiment test two potential mechanisms for concealment appendages: (1) reduction edge intensity (2) lumi...

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review...