case a 13-year-old boy presented to the ski clinic following a fall and a possible twisting of his right knee. he was not able to bear any weight on his right leg and was experiencing pain in the medial aspect of his right knee. his past medical and surgical histories were unremarkable and he was otherwise in good health. physical examination revealed no ecchymosis or effusion. he had moderate ...

In this study, we compared the effects of SKI-606 with Iressa, Src/Abl and EGF-R kinase inhibitors, respectively, on selected parameters in HeLa and SiHa cervical cancer cell lines, which express E6/E7 oncoproteins of high-risk HPV types 18 and 16, respectively. Our results show that SKI-606 and Iressa inhibit cell proliferation and provoke G(0)-G(1) cell cycle arrest and reduction of S and G(2...

The Smad proteins are key intracellular effectors of transforming growth factor-beta (TGF-beta) cytokines. The ability of Smads to modulate transcription results from a functional cooperativity with the coactivators p300/cAMP-response element-binding protein-binding protein (CBP), or the corepressors TGIF and Ski. The c-Jun N-terminal kinase (JNK) pathway, another downstream target activated by...

Roller skis are used by cross-country skiers, biathletes and ski-orienteers for their snow-free training and in roller ski competitions. Additionally, much of the current sports research into the physiology and biomechanics of crosscountry skiing is conducted indoors on treadmills using roller skis. For elite athletes, the differences in performance are quite small, thus emphasising the importa...

Mountain regions have been identi fied as especially vulnerable areas to climate change. Changes in snowfall, glacier retreat and shifts in biodiversity amount and distribution are some examples of the sensitivity of mountain ecosystems. Moreover, in many mountain economies, reliable snow cover plays a key role as an important resource for the winter tourism industry, the main income source and...

Sphingosine kinase (Sphk) has been shown to be activated by growth factor and survival factors, and one of its products, sphingosine-1-phosphate, plays an important role in the regulation of various cellular responses. However, the effect of Sphk on the maturation and immunostimulatory function of dendritic cells (DCs) still remains largely unknown. In this study, we examined whether sphingosin...

Resistance to imatinib represents an important scientific and clinical issue in chronic myelogenous leukemia. In the present study, the effects of the novel inhibitor SKI-606 on various models of resistance to imatinib were studied. SKI-606 proved to be an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines and transfectants, with IC(50) values in the low nanomolar ra...

Vertebrate members of the ski/snoN family of proto-oncogenes antagonize TGFβ and BMP signalling in a variety of experimental situations. This activity of Ski/SnoN proteins is related to their ability to interact with Smads, the proteins acting as key mediators of the transcriptional response to the TGFβ superfamily members. However, despite extensive efforts to identify the physiological roles ...