BACKGROUND Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in early humans, and inferred from M. tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should...

The assessment of therapeutic remedies for tuberculosis is notoriously difficult : many remedies in the past have enjoyed popular favour but have been forgotten ; many papers have been written on calcium or tuberculin or gold, but who now refers to them? These thoughts must have been in the minds of the Medical Research Council in 1946 when they undertook to plan trials of streptomycin in pulmo...

Tubercular mastitis is a rare clinical entity as mammary gland tissue, like spleen and skeletal muscle, offers resistance to the survival and multiplication of the tubercle bacillus. Tuberculosis of the breast can mimic carcinoma, whereas in young patients it can be mistaken for a pyogenic breast abscess, thus labeled a "great masquerader" in recognition of its multifaceted ...

Tuberculosis is a systemic disease which involves skeletal and articular system very rarely. Osteoarticular tuberculosis commonly occurs in the vertebral column and more rarely in the sacroiliac joints. In this study, we report a 44-years-old male patient with low-grade fever, malabsorption syndrome, abdominal and pelvic ascites and low-back pain, that underwent 18F-FDG PET/CT for identifying t...

Tuberculosis is a major health problem in developing nations. Spine is the most commonly affected site for skeletal tuberculosis but involvement of sacrum is rare. Isolated involvement of sacrum has been reported in literature but none of the reports has mentioned its clinical presentation as monoparesis. Our case presented with symptoms of sensory and motor deficit in right lower limb. The mag...

Tuberculosis is a world wide communicable disease caused by tubercle bacilli discovered by Robert Kock in 18821,2,3. In 1993 WHO declared TB as a global emergency due to its world wide resurgence2,4. It can involve any organ of the body1,2. Abdomen is the fourth commonest site of involvement in the extra pulmonary tuberculosis after the lymph-nodes, skeletal and Genito urinary variants1. In the...

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Tuberculosis is a contagious disease that usually attacks the lungs but sometimes attacks other parts of the body, such as the kidneys, glands, and bones. It is an endemic and major public health problem in Morocco. Tuberculosis is transmitted through the airways via the inhalation of microdroplets containing Mycobacterium tuberculosis We present here the whole-genome shotgun sequences of three...

INTRODUCTION Afflictions of shoulder by tuberculosis is rare and when it occurs its more commonly a dry lesion (caries sicca). Wet lesions in shoulder are rare and we report this case for the rarity of its occurrence. CASE REPORT A 55yrs old female patient presented with a painful swelling with restriction of movements of the right shoulder since six months. Patient had taken various treatmen...

Primary tubercular osteomyelitis of sternum is a rare clinical entity and involvement of manubrio-sternal joint is even rarer, with only few cases reported in the literature. Tuberculous sternal involvement is seen in approximately 1% of all skeletal TB cases. We report an unusual case of primary manubrio-sternal joint tuberculosis presenting as vague anterior chest wall swelling and pain. ESR ...