Musculoskeletal disorders merupakan keluhan yang terjadi dibagian otot rangka (skeletal). Desain stasiun kerja digunakan oleh pekerja dapat mempengaruhi posisi dan kenyamanan saat bekerja, sehingga risiko untuk merasakan musculoskeletal akan semakin rendah. Penelitian ini bertujuan menganalisis hubungan postur desain pada aktivitas penjemuran dengan laundry di Kelurahan Tembalang. Jenis penelit...

Bulimia nervosa and anorexia are among the most common chronic, psychosocial pathological eating disorders. Fear of obesity is main element in both diseases. Restricted food intake associated with extreme weight loss characteristic anorexia. characterized by repeated episodes uncontrolled unrestricted followed starvation, self-induced vomiting, or laxatives. Eating disorders have severe consequ...

Type II collagen is a homotrimeric molecule composed of three identical al(II) collagen chains that are synthesized as precursor procollagens with aminoand carboxy-terminal propeptides that are removed extracellularly. Mutati'ons in the ol(II) .chain result in disproportionate dwarfing disorders in the spectrum of skeletal dysplasias,' Hitherto, only the propeptides' sequences have been publish...

LMNA-related disorders are caused by mutations in the LMNA gene, which encodes for the nuclear envelope proteins, lamin A and C, via alternative splicing. Laminopathies are associated with a wide range of disease phenotypes, including neuromuscular, cardiac, metabolic disorders and premature aging syndromes. The most frequent diseases associated with mutations in the LMNA gene are characterized...

Skeletal disorders that need effective studies in suitable animal models include "osteoporosis", arthroses and hard and soft tissue healing. For people doing or analyzing such studies this article provides a brief overview and some salient implications of the Utah paradigm of skeletal physiology. The article leaves discussing and resolving any disagreements and controversies about such things t...

Mitochondria play a key role in the energy metabolism in skeletal muscle. A new concept has emerged suggesting that impaired mitochondrial oxidative capacity in skeletal muscle may be the underlying defect that causes insulin resistance. According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal musc...

Skeletal stem cells (SSCs) reside in the postnatal bonemarrowand give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes indefined in vivoassays.These lineagesemerge inaspecific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marroworgan.SSCsconjoin skeletal andhematopoieticphysiology, a...

Three fundamental types of cephalic axial skeletal-neural dysrapic disorders are analyzed, including: cranioschisis aperta with encephaloschisis (anencephaly and/or exencephaly), cranioschisis occulta with occipital encephalocele, and the Chiari malformation (occipital bone hypoplasia) with compression, deformation and displacement of hindbrain, cerebellum, and medulla. Both clinical and experi...

Osteoporosis is a skeletal disease characterized by low bone mass associated with decreased strength and increased risk of fractures. Low in premenopausal women less common than postmenopausal women, loss usually due to secondary causes such as estrogen deficiency, glucocorticoid exposure, malabsorption, thyroid disorders, hyperparathyroidism. In osteoporosis, treatment should be planned accord...

High-fat diet (HFD) plays a central role in the initiation of mitochondrial dysfunction that significantly contributes to skeletal muscle metabolic disorders in obesity. However, the mechanism by which HFD weakens skeletal muscle metabolism by altering mitochondrial function and biogenesis is unknown. Given the emerging roles of microRNAs (miRNAs) in the regulation of skeletal muscle metabolism...