Two new loci found in one strain of Neurospora crassa (P2604) collected in Malaya are related to the meiotic drive system Spore killer Sk-2. Sk-2 was found in Neurospora intermedia and introgressed into N. crassa. P2604 showed high resistance to killing when crossed to Sk-2. This resistance was found to be linked to, but not allelic to, resistance locus r(Sk-2) on LGIIIL. Analysis showed that t...

Shikonin (SK), a natural naphthoquinone isolated from the Chinese medicinal herb, has been known to suppress the proliferation of several cancer cells. However, its role in the epithelial mesenchymal transition (EMT) has yet to be demonstrated. The aim of the present study was to examine the effects of SK on EMT. Lipopolysaccharide (LPS) induced EMT-like phenotypic changes, enhancing cell migra...

The Super-Kamiokande (SK) water Cherenkov detector has been operating for nearly 12 years collecting data for the study of both solar and atmospheric neutrinos as well as searching for neutrinos from supernovæ(and relic supernovæ) and for nucleon decay. The experiment has undergone three operating phases during the full running period: SK-I (40% photocathode coverage), SK-II (20% coverage), and...

A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct from the known 'calcium antagonists' and shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release. Human platelets, neutrophils and endothelial cells were loaded with ...

PSA is a 33-KDa serine protease that is produced predominantly by prostate epithelium. However, it has been shown that about 30-40% of female breast tumors produce PSA and its production is associated with the presence of estrogen and progesterone receptors. We have now developed a new tissue culture system to study PSA production in breast cancer and its association with prognostic factors...

Let X1,X2,… be independent, identically distributed random variables taking values from a compact metrizable group G. We prove that the walk Sk=X1X2⋯Xk, k=1,2,… equidistributes in any given Borel subset of G with probability 1 if and only X1 is not supported on proper closed subgroup G, Sk has an absolutely continuous component for some k≥1. More generally, sum ∑k=1Nf(Sk), where f:G→R measurabl...

*Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Center for Veterinary Drug Residues, Canadian Food Inspection Agency, Saskatoon Laboratory, Saskatoon, SK, Canada; Departm...

The effect of intravenous streptokinase (SK) on time course of creatine kinase-MB (CK-MB) release and rapid reduction in ST-segment elevation as two non-invasive markers of reperfusion was prospectively studied in 83 patients with first anterior wall AMI (SK group, n = 61; control group, n = 22). CK-MB evidence of reperfusion in the SK group was significantly higher than that in the control gro...

Continuing efforts are being made to improve thrombolytic therapy for acute myocardial infarction (AMI). The rate of streptokinase (SK) infusion is commonly limited by the hypotension that is induced. If this could be avoided, an accelerated regimen of SK could be given, analagous to that used for other thrombolytic agents such as alteplase. The mechanism of the SK-induced hypotension is unknow...

Lymphatic metastasis is a poor prognostic factor in ovarian cancer, which correlates to the majority of cancer deaths. Matrix protein (MP) of vesicular stomatitis virus (VSV) exhibits potent antitumor and antiangiogenic activities through inducing apoptosis and inhibiting angiogenesis. In this study, the antitumor and antimetastatic effects of MP were further investigated. Wild-type SKOV3 (WT-S...