In situ ophthalmic gel is a type of eye drug preparation that has higher bioavailability value and longer contact time with maximum therapeutic effect minimal side effects compared to conventional preparations. The in required characterization make sure the prepared preparations meet standards are safe when used. This journal review aims look at methods used characterizing physical properties f...

Indian Journal of Pharmaceutical Sciences 711 November December 2009 In conclusion, liposomal dispersion of FP was successfully prepared with more than 90% entrapment. Spray dried liposomes had mean size of 3-4 μ and FPF of 9-10%. Inclusion of antistatic agents such as leucine and magnesium stearate did not improve the aerosolisation behaviour of DPIs in this study. Further studies are warrante...

An enzyme that plays an important role in the repair of oxidative DNA damage is the 3'-phosphodiesterase. This activity, which repairs damaged DNA 3'-termini,can be detected using several available biochemical assays. We present a method to detect 3'-phosphodiesterase activity of renatured proteins immobilized in polyacrylamide gels. The model substrate, labeled with [alpha-32P]dCTP, contains 3...

Henriksson, S. 2010. Application of Padlock Probe Based Nucleic Acid Analysis In Situ. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 575. 41 pp. Uppsala. ISBN 978-91-554-7842-1. The great variation displayed by nucleic acid molecules in human cells, and the continuous discovery of their impact on life, consequently require ...

OBJECTIVES The study aims at applying pharmaceutical nanotechnology and D-optimal fractional factorial design to screen and optimize the high-risk variables affecting the performance of a complex drug delivery system consisting of glimepiride-Zein nanoparticles and inclusion of the optimized formula with thermoresponsive triblock copolymers in in situ gel. METHODS Sixteen nanoparticle formula...

This paper reports on a rapid new method for in-situ sol-gel deposition of silica layers in PDMS microchannels. A two-step process is used; first allowing TEOS to diffuse briefly into the channel, followed by acid catalysed hydrolysis and condensation. The silica coating results in an increased and stabilised electroosmotic flow. With this novel method there is no need for pretreatment of the m...

The present investigation deals with the formulation, optimization and evaluation of sodium alginate based floating oral In situ gel of Pantoprazole. Sodium alginate used as a polymer and Calcium carbonate was used as a crosslinking agent. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-si...