Changes in cellular nutrient availability or energy status induce global changes in mitochondrial protein acetylation. Over one-third of all proteins in the mitochondria are acetylated, of which the majority are involved in some aspect of energy metabolism. Mitochondrial protein acetylation is regulated by SIRT3 (sirtuin 3), a member of the sirtuin family of NAD+-dependent protein deacetylases ...

Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability suppress Amyloid-beta (Aβ) plaques formation. It is found that people with have lower expression of Sirtuin-1 because the oxidative stress was produced by Aβ plaques. Objective: To observe gene in rat models AlCl3 inducing after being given MSC-WJ. Methods: This an experimental st...

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date SIRTUIN 3 IS A CRITICAL REGULATOR OF LIVER SUPEROXIDE METABOLISM DURING EARLY AND LATE EFFECTS OF WHOLE BODY

Sirtuins are protein deacylases regulating metabolism and aging processes, and the seven human isoforms are considered attractive therapeutic targets. Sirtuins transfer acyl groups from lysine sidechains to ADP-ribose, formed from the cosubstrate NAD(+) by release of nicotinamide, which in turn is assumed to be a general Sirtuin inhibitor. Studies on Sirtuin regulation have been hampered, howev...