BACKGROUND & AIMS In acute liver failure, severity of liver injury and clinical progression of disease are in part consequent upon activation of the innate immune system. Endotoxaemia contributes to innate immune system activation and the detoxifying function of albumin, critical to recovery from liver injury, is irreversibly destroyed in acute liver failure. University College London-Liver Dia...

INTRODUCTION We conducted this study to measure hemodialysis adequacy and determine to what extent some Kidney Disease Outcomes Quality Initiative (KDOQI) goals are achieved in our patients. MATERIALS AND METHODS In a cross-sectional study in Fars province, Iran, we assessed 632 patients on hemodialysis in 15 dialysis centers. The Kt/V was calculated, and data on serum levels of albumin, chol...

BACKGROUND To assess the need to adapt dietary prescriptions, we studied potential effects of increasing the dialysis dose by adding a daytime icodextrin dwell, in children on Nocturnal Intermittent Peritoneal Dialysis (NIPD), on peritoneal amino acids (AA) and albumin loss, AA, albumin, cholesterol and fibrinogen plasma levels and nutritional intake. METHODS A cross-over study in eight child...

BACKGROUND AND OBJECTIVES Peritoneal clearance of albumin-unlike the transport of small molecules-is defined by both vascular surface area and size-selective permeability. Few studies have supported a positive correlation between peritoneal albumin loss and mortality. The aim of this study was to investigate whether baseline peritoneal loss and clearance of albumin and other proteins is a risk ...

A mathematical model for fluid and solute transport in peritoneal dialysis is constructed. The model is based on a threecomponent nonlinear system of two-dimensional partial differential equations for fluid, glucose and albumin transport with the relevant boundary and initial conditions. Our aim is to model ultrafiltration of water combined with inflow of glucose to the tissue and removal of al...

The binding of aurothiomalate to human serum albumin was studied by equilibrium dialysis at 37 degrees C, pH 7.3-7.4, and ionic strength 0.15-0.16 mol/l. It was found that aurothiomalate was bound to albumin at one site with an apparent association constant K1 = 3.0 X 10(4) M-1 and at three or more sites with the sum of association constants of the order of 10(3) M-1. Valuable information of th...

The postulate that thyroxine (T4) in plasma enters tissues by protein-mediated transport or enhanced dissociation from plasma-binding proteins leads to the conclusion that almost all T4 uptake by tissues in the rat occurs via the pool of albumin-bound T4 (Pardridge, W. M., B. N. Premachandra, and G. Fierer. 1985. Am. J. Physiol. 248:G545-G550). To directly test this postulate, and to test more ...

Abstract Background and Aims The glomerular filtration rate (GFR) decline varies in patients with advanced chronic kidney disease (CKD), the concurrent changes CKD-related biomarkers are unclear. Method We adopted a group-based trajectory model to categorize CKD by their pre-dialysis eGFR then analyzed changing trends of CKD-relevant biomarkers, including urine protein-creatinine ratio (UPCR), ...

BACKGROUND Recent observations have associated hypomagnesemia with increased risk of cardiovascular morbidity and mortality in hemodialysis patients. METHODS We did a 3-month chart review of 62 chronic hemodialysis patients at a single US hospital. All were dialyzed using a dialysate [Mg] of 0.75-1.0 mEq/l. Patients were divided into two groups: hypomagnesemic (mean predialysis plasma [Mg] <1...

Nutritional status refers to the composite quantitative and qualitative assessment of visceral and somatic (muscle) protein stores and energy balance (1,2). Evaluating nutritional status is a critical component of physiologic health and fundamental to identifying protein-energy wasting (PEW), a condition highly prevalent and strongly correlated with increased morbidity and mortality in patients...