We study the impact of optimizing the side-chain positions in the interface region between two proteins during the process of binding. Mathematically, the problem is similar to side-chain prediction, which has been extensively explored in the process of protein structure prediction. The protein-protein docking application, however, has a number of characteristics that necessitate different algo...

Interpretive signs provide an important tool for enhancing visitor knowledge and understanding during a natural area experience. The Tree Top Walk (TTW) site in Western Australia adopted a minimal approach to interpretive signs to reduce distractions and allow the site to speak for itself. A 1999 pilot visitor survey indicated that many visitors were frustrated at this approach and wanted more ...

The objective of this research is to develop neck injury criteria and injury tolerance levels to be used as a basis for a performance standard for the certification of side facing aircraft seats. This paper presents the results of the first part of this study. A literature review was performed on the neck injuries, kinematics and injury mechanisms in lateral loading and existing injury criteria...

Over 17,000 non-struck or far side occupants in side and rollover crashes are seriously or fatally injured annually in the US. Although no legal or rating tests exist for far side crashes, test methods including appropriate dummies as well as countermeasures have been recently suggested. The aim of this study was to establish the incidence and risk of injury / fatality as a function of vehicle ...

Near side impact crashes – especially pole impacts – have the potential to induce antero-lateral oblique loads to the chest. Current side impact dummies and most laboratory experimental studies have been designed to assess direct lateral impacts. A recent analysis of real world crashes indicated that the human chest experiences oblique loading in side impact crashes – in particular crashes into...

BACKGROUND The optimal strategy in percutaneous coronary intervention (PCI) for coronary artery bifurcation lesions has yet to be agreed upon. We compared a strategy for stenting the main vessel to provide a complete perfusion flow in the side branch, namely thrombolysis in myocardial infarction (TIMI) - III, with a strategy for intervention in both the main vessel and the side branch (MV + SB)...

With the advent of powerful computers, vehicle safety issues have recently been addressed using computational methods of vehicle crashworthiness, resulting in reductions in cost and time for new vehicle development. Vehicle design demands multidisciplinary optimization coupled with a computational crashworthiness analysis. However, simulation-based optimization generates deterministic optimum d...

introduction: the role of different parts of the extended amygdala in metabolic signs of stress is not well understood. in the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (nac) on metabolic disturbance induced by electro foot shock stress using transient inactivation method in the rat.  methods: male wistar rats (w: 230-250 g) were canuulated unilater...

Occupant injury in real world vehicle accidents can be significantly affected by a set of crash characteristics, of which impact direction and impact location (or damage location) in general scale interval (e.g., frontal impact is frequently defined as general damage to vehicle frontal end with impact angle range of 11-1 o'clock) have been identified to associate with injury outcome. The effect...

This paper presents an application of a new stochastic programming method for vehicle side impact design. Nonlinear response surface models are employed as the 'real' models for the side impact related performance functions to conduct this study. The main goal is to enhance vehicle side impact crash performance while minimizing vehicle weight under various uncertainties. The new algorithm allev...