background: there are many parameters that modulate the severity of sickle cell anemia. fetal hemoglobin (hb f) is one of these major variables. however, its effect is clinically inconsistent. we conducted a descriptive study to assess the influence of hb f on clinical events and hematological variables in patients with sickle cell anemia. methods: 151 patients with sickle cell anemia with a st...

Abstract The study aimed to discover the role of vitamin D in improving respiratory function sickle cell disease patients. In this prospective study, 188 adults were enrolled, drawn from out-patients unit Thalassemia Cente collected data categorized into three groups: group 1 included 100 healthy individuals age range 18-50 years as control; 2 88 (40 males and 48 females) patients steady state ...

Executive function and processing speed difficulties are observed in children living with sickle cell anemia (SCA). The influence of on executive is not well understood. We recruited 59 SCA 24 matched controls aged 8–18 years between 2010 2016 from clinics the UK. Children completed tests cognitive flexibility, subdomains function. MRI scans were conducted within one year testing; oxygen satura...

background: the aim of the present study was application of haemoglobin absorption spectroscopy as a distinguishing tool for identification of two haemoglobin types-hba and hbs. material and methods: millimolar absorptivities of normal adult haemoglobin (hba) and sickle cell haemoglobin (hbs) were monitored at ph values of 7.2 and 5.0, within the ultra violet and visible spectral range (250-650...

the restriction enzyme ava ii detects the base change of the intervening sequence ii (ivs ii) which is used as one of the markers of β-globin gene polymorphism. this study was conducted to determine the frequency of the ava ii site on the β-globin gene among normal people and patients with sickle cell syndrome (scs) in iran. dna fragments containing the ivs ii region of the β-globin gene from 3...

Background: Sickle cell anemia is relatively common in Khuzestan province located in Southwest Iran. The characteristics of sickle cell disease in Iran are apparently different from other regions some of these characteristics might be related to β-chain haplotypes. The purpose of this study was to determine the frequency of β-chain haplotypes in 50 patients with homozygous sickle cell anemia in...

Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell disease. Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether stimulation of NO-signaling pathways can reduce the adhesive properties of neutrophils from sickle cell disease individuals (sickle cell diseasene...

Sickle cell anemia results from a single amino acid substitution in the gene encoding the β-globin subunit. Polymerization of deoxygenated sickle hemoglobin leads to decreased deformability of red blood cells. Hashimoto's thyroiditis is a common thyroid disease now recognized as an auto-immune thyroid disorder, it is usually thought to be haemolytic autoimmune anemia. We report the case of a 32...

OBJECTIVE To correlate spleen function with soluble transferrin receptor (sTfR) levels and red cell ferritin (RCF) values in patients with sickle cell diseases. DESIGN Prospective study. LOCATION University Hospital, School of Medical Sciences, State University of Campinas; a tertiary hospital. PARTICIPANTS 60 patients with sickle cell diseases, in a steady state, who had not received blo...