Sialic acid of seminal fluid of eighty two human subjects has been studied in relation to infertility. Normozoospermic group had highest sialic acid content (94 mgm/100 mt of the fluid) and was sign ificantly different from other groups. The lowest sialic acid level was observed: n necrozoosperm ic group (54 mgm/1 00 mt of the fluid). Azoospermic (62 mgm/100 ml) and vasectomised group (73 mgm/1...

In recent years, the biological functions of human milk oligosaccharides and potential toxic effects red meat on health have attracted considerable attention. Sialic acid is an important carbohydrate in meat, corresponding to sialylated N-glycolylneuraminic (NeuGc, one type sialic acid). Herein, we reviewed metabolic fate dietary body their gut oral microbes. summary, NeuAc monomer directly exc...

Active inclusion bodies of polyphosphate kinase 3 and cytidine 5'-monophosphate kinase were combined with whole cells that co-express sialic acid aldolase and CMP-sialic acid synthetase. The biocatalytic mixture was used for the synthesis of CMP-sialic acid, which was then converted to 3'-sialyllactose by whole cells.

Focusing on the high dispersion of stable isotope ratios (δ13C, δ15N, δ18O, δ2H) in edible bird's nest (EBN), a robust method was developed to simultaneously discriminate and quantify three types substances (sialic acid, egg white food gums) added separately into EBN. Results showed that by establishing data processing formula improve cohesion samples' ratios, discriminant achieved with an accu...

A defective efflux of free sialic acid from the lysosomal compartment has been found in the clinically heterogeneous group of sialic acid storage disorders. Using radiolabeled sialic acid (NeuAc) as a substrate, we have recently detected and characterized a proton-driven carrier for sialic acid in the lysosomal membrane from rat liver. This carrier also recognizes and transports other acidic mo...

1. Although glycoproteins with less than 1% of sialic acid (fibrinogen, lipoproteins, gamma-globulins) interact electrostatically with chondromucoprotein to form insoluble complexes, interaction with glycoproteins containing larger amounts of sialic acid (orosomucoid, urine glycoprotein, seromucoid, fraction VI) was electrostatically impossible. Reasons for this are discussed. 2. The latter gly...

B-Lymphotropic Polyomavirus (LPyV) serves as a paradigm of virus receptor binding and tropism, and is the closest relative of the recently discovered Human Polyomavirus 9 (HPyV9). LPyV infection depends on sialic acid on host cells, but the molecular interactions underlying LPyV-receptor binding were unknown. We find by glycan array screening that LPyV specifically recognizes a linear carbohydr...

Inhibitory components in myelin are largely responsible for the lack of regeneration in the mammalian CNS. Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo. Here, we show that MAG's sialic acid binding site is distinct from its neurite inhibitory activity....

Sialic acids are a subset of nonulosonic acids, which are nine-carbon alpha-keto aldonic acids. Natural existing sialic acid-containing structures are presented in different sialic acid forms, various sialyl linkages, and on diverse underlying glycans. They play important roles in biological, pathological, and immunological processes. Sialobiology has been a challenging and yet attractive resea...