نتایج جستجو برای: shv بتالاکتاماز

تعداد نتایج: 1355  

Journal: :Antimicrobial agents and chemotherapy 2000
J K Rasheed G J Anderson H Yigit A M Queenan A Doménech-Sánchez J M Swenson J W Biddle M J Ferraro G A Jacoby F C Tenover

Klebsiella pneumoniae K6 (ATCC 700603), a clinical isolate, is resistant to ceftazidime and other oxyimino-beta-lactams. A consistent reduction in the MICs of oxyimino-beta-lactams by at least 3 twofold dilutions in the presence of clavulanic acid confirmed the utility of K. pneumoniae K6 as a quality control strain for extended-spectrum beta-lactamase (ESBL) detection. Isoelectric-focusing ana...

2015
Abbas Doosti Mohammad Pourabbas Asghar Arshi Mohammad Chehelgerdi Hamidreza Kabiri

OBJECTIVES Klebsiella pneumoniae is a gram-negative rod bacterium, a known cause of community-acquired bacterial pneumonia and is an important hospital-acquired pathogen that causes severe morbidity and mortality. The aim of this study was to identify the TEM and SHV genes in K. pneumoniae isolated from cockroaches obtained from hospitals. METHODS In this study, 250 cockroaches were collected...

 مقدمه و هدف: آنزیم‌های بتالاکتاماز مهمترین عامل مقاومت نسبت به آنتی‌بیوتیک‌های گروه بتالاکتام در میان باکتری‌های گرم منفی می‌باشند. در سال‌های اخیر، تولید آنزیم‌های بتالاکتاماز وسیع الطیف (ESBLs) در میان باکتری‌ها به ویژه باکتری‌های با منشا دامی شیوع فراوانی یافته و این موضوع از لحاظ بهداشت عمومی حائز اهمیت می‌باشد. هدف از این مطالعه ارزیابی حضور ژن‌هایblaSHV و blaCTX-M در جدایه‌های اش...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه گیلان - دانشکده علوم پایه 1393

تولید بتا لاکتامازهای وسیع الطیف (esbls) از مهمترین مکانیسم های مقاومت به آنتی بیوتیک های بتالاکتام می باشد. این آنزیم ها باعث هیدرولیز سفالوسپورین های نسل سوم و چهارم می شوند. رایجترین انواع esblها مشتقات tem و shv می باشند. tem ها باعث مقاومت به پنی سیلین، آمپی سیلین و سفالوسپورین های نسل اول مثل سفالوتین و shv ها نیز باعث مقاومت به پنی سیلین و سفالوسپورین های نسل اول می شوند. با توجه به این ...

2009
Amita Jain Rajesh Mondal

Background & objectives: Extended spectrum β-lactamases (ESBLs) are often plasmid mediated derived from mutations in the classic TEM and SHV genes by one or more amino acid substitution around the active site. Detection of TEM and SHV genes by molecular methods in ESBL producing bacteria and their pattern of antimicrobial resistance can provide useful information about its epidemiology and risk...

2016
Apostolos Liakopoulos Dik Mevius Daniela Ceccarelli

β-lactamases are the primary cause of resistance to β-lactams among members of the family Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections in health care in the last decades of the Twentieth century, and they are now observed in isolates in different epidemiological settings both in human, animal and the environment. Likely originated from a chromosomal peni...

Journal: :Nihon rinsho. Japanese journal of clinical medicine 2001
Y Hirakata

TEM- or SHV-type extended-spectrum beta-lactamases(ESBLs) are of clinical concern in Europe and the United States, whereas bacterial strains producing such types of ESBLs had not been reported in Japan for many years. Toho-1, a different type class A ESBL, has been reported in 1995, in which any prototypical enzyme has not been identified so far. At present Toho-1 is the major ESBL in Japan, ho...

Journal: :Antimicrobial agents and chemotherapy 2002
T Spanu F Luzzaro M Perilli G Amicosante A Toniolo G Fadda

An Italian nationwide survey was carried out to assess the prevalences and the antimicrobial susceptibilities of members of the family Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs). Over a 6-month period, 8,015 isolates were obtained from hospitalized patients and screened for resistance to extended-spectrum cephalosporins and monobactams. On the basis of a synergistic ...

Journal: :Antimicrobial agents and chemotherapy 2011
Wei Ke Jared M Sampson Claudia Ori Fabio Prati Sarah M Drawz Christopher R Bethel Robert A Bonomo Focco van den Akker

Boronic acid transition state inhibitors (BATSIs) are potent class A and C β-lactamase inactivators and are of particular interest due to their reversible nature mimicking the transition state. Here, we present structural and kinetic data describing the inhibition of the SHV-1 β-lactamase, a clinically important enzyme found in Klebsiella pneumoniae, by BATSI compounds possessing the R1 side ch...

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