BACKGROUND For reasons of simplicity, studies on isolated human myocardium have been conducted using exclusively isometric contractions, although positive inotropic interventions may differently influence force development, extent of shortening and myocardial work performance. We investigated human left ventricular failing and non-failing preparations comparing isometric versus isotonic, i.e., ...

To determine the effect of myocardial shortening velocity on the duration of electrical and mechanical systole, five healthy men, ages 32 to 41, were studied. Carotid message and atropine were used to define the effects of changes in heart rate without changes in shortening rate. The effects of amyl nitrite, which produced approximately the same degree of tachycardia as atropine but a significa...

PURPOSE We hypothesized that radial shortening osteotomy (radial shortening) for skeletally immature patients with Kienböck's disease would induce overgrowth of the radius. The purpose of this study was to determine the effect of radial shortening on radial growth in skeletally immature patients with Kienböck's disease and to clarify the relationship between the postoperative growth alterations...

The polysyllabic shortening hypothesis holds that the duration of a primary stressed syllable is inversely proportional to the number of additional syllables within the word. We examine the evidence for this process in British English speech by measuring the duration of primary stressed syllables in monosyllabic, disyllabic and trisyllabic words, both right-headed series – e.g. mend, commend, r...

This study examined how duration of an unstressed final syllable in English is affected by conditions in the following word: stress (trochaic/iambic), accent (accented/unaccented), and initial stop voicing (voiced/voiceless). Results showed that the unstressed final syllable was shorter before an unstressed syllable, presumably due to polysyllabic shortening—i.e., the following unstressed sylla...

telomeres can cause problems. J Gerontol A Biol Sci Med Sci 2010;65A:789–91. 29. Lorenz M, Saretzki G, Sitte N, Metzkow S, von Zglinicki T. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med 2001;31:824–31. 30. Bodnar AG, Ouellette M, Frolkis M et al. Extension of life-span by introduction of telomerase into norma...

The effect of coronary artery bypass grafts on left ventricular performance was evaluated by analyzing preoperative (preop) and postoperative (postop) biplane left ventriculograms of 37 patients who were restudied at a mean of 13 months after operation. Eighty-two percent of the grafts were patent. Segmental wall shortening and segmental shortening velocities (mea Vcf) in the anterior, inferior...

BACKGROUND Most antiepileptic drugs (AEDs) inhibit seizure generation by acting on voltage-dependent ion channels. Voltage-dependent sodium and calcium channels are commonly expressed in brain and heart, suggesting that AEDs may have considerable cardiodepressive effects, thereby facilitating sudden cardiac death as a potential cause of sudden unexpected death in epilepsy. Here, we investigated...