BACKGROUND The SH2-containing-5'inositol phosphatase-1 (SHIP) influences signals downstream of cytokine/chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1/CXCL-12 and interleukin-3. We hypothesize that SHIP might control megakaryocytopoiesis through effects on proliferation of megakaryocyte progenitors (MKP) and megakaryocytes (...

To clarify the role that the src homology 2-containing inositol phosphatase (SHIP) plays in mast cell degranulation, the gene for SHIP was disrupted by homologous recombination in embryonic stem cells. Bone-marrow-derived mast cells from SHIP+/+, +/-, and -/- F2 littermates were compared. SHIP-/- mast cells were found to be far more prone to degranulation, after the crosslinking of IgE preloade...

Spark-ignition engines exhibit patterns of increasing instability as engine fueling goes from stoichiometric to lean. The observation of time irreversibility in cycleresolved combustion measurements indicates that this combustion instability is inherently nonlinear. Using time return maps and symbolic time-series analysis, we demonstrate the presence of strong time irreversibility in experiment...

BACKGROUND Inflammatory bowel disease (IBD) can arise from genetic mutations that compromise intestinal epithelial cell integrity or immune regulation. SHIP has previously been shown to play a pivotal role in limiting the number of immunoregulatory cells and their function. AIM To determine whether SHIP plays a pivotal role in control of immune tolerance in the gut mucosa. METHODS Gastroint...

For ship detection, X-band synthetic aperture radar (SAR) imagery provides very useful data, in that ship targets look much brighter than surrounding sea clutter due to the corner-reflection effect. However, there are many phenomena which bring out false detection in the SAR image, such as noise of background, ghost phenomena, side-lobe effects and so on. Therefore, when ship-detection algorith...

In order to reduce the conflict of yard, vehicles and quay crane in the process of loading container, and upgrade safety of the ship stowage and transport economics, this paper took minimizing reshuffle times in yard and ship, minimizing the ship center of gravity, getting appropriate trim and minimizing the total moving distance of quay crane as optimization objectives to guarantee the balance...

As a precursor to capsize, marginal stability, resulting from incorrect loading conditions and crew negligence, poses a serious danger to ships. Therefore, as a benchmark problem for preventing capsize, the use of an actively controlled pendulum for the stabilization of a marginally stable ship was analyzed. Lyapunov stability criteria and closed loop eigenvalues were used to evaluate the exten...

Recent molecular line observations with ALMA in several nearby Seyferts have revealed the existence of tori, and nature gas flows at 10-20 pc scale. At 100 scale, or kpc-scale, previous NOEMA work on gravitational torques had shown that only about one third Seyfert galaxies experienced inflow central fueling, while most cases was stalled rings. higher resolution, i.e. it is possible now to see ...

The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been observed in SHIP-null mice, but it is unclear whether they are due to an intrinsic ...