Pain and discomfort are common and often severe skin symptoms in patients with psoriasis. However, no studies have investigated skin pain and discomfort over time, or factors that explain changes in these symptoms. The aims of the present study were to describe the changes in skin pain, skin discomfort and Psoriasis Area and Severity Index (PASI) over time, and to investigate whether change in ...

Background: Numerous studies have analyzed the influence of psoriasis on quality life and psychological health patients. 0nly few addressed effect disease individuals cohabitants psoriatic patients in developing countries, none Bangladesh. Objective: To assess clinical severity, physical psychosocial disability to analyze their interrelationship cohabitants. Methods: Hospital based cross-sectio...

chronic plaque-type psoriasis may be difficult to control without the use of potent systemic therapies that are accompanied by systemic toxicity. mycophenolate mofetil is a novel agent that may be effective in the treatment of chronic plaque type psoriasis. our purpose was to investigate of the safety and efficacy of oral mycophenolate mofetil in the treatment of chronic plaque-type psoriasis. ...

PURPOSE This retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity. MATERIALS AND METHODS We undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compar...

Background. Serum ghrelin levels may be related to metabolic and clinical changes in patients with psoriasis. Objective. This study was performed to determine the possible effects of serum ghrelin in patients with psoriasis. Methods. The study population consisted of 25 patients with plaque psoriasis. The patients were questioned with regard to age, gender, age of onset, duration of disease, he...

OBJECTIVE To compare the therapeutic efficacy of narrowband (TL-01) UV-B phototherapy vs photochemotherapy (psoralen-UV-A [PUVA]) in patients with chronic plaque-type psoriasis. DESIGN Open, nonrandomized, intraindividually controlled paired comparison study. SETTING Phototherapeutic unit in a university hospital. PATIENTS Twenty-five patients with chronic plaque-type psoriasis. INTERVE...

BACKGROUND Quality of life (QOL) is increasingly recognized as an important outcome measure in dermatology. Psoriasis has a great impact on QOL of patients, and has a strong effect on social relations, psychological status, and daily activities. This study describe and compare the impact of different grades of severity of psoriasis on QOL of patients in north of Iran. METHODS This cross-secti...

BACKGROUND To provide evidence that the Chinese herbal medicine (CHM) PSORI-CM01 combined with Western medicine reduces the relapse rate of psoriasis vulgaris (PV), we plan to conduct a large-scale randomized control trial (RCT). In order to improve and perfect the RCT, this pilot study was designed to determine the feasibility and the potential of a modified protocol for the full-scale RCT. ...

There are limited data on the safety and efficacy of switching to secukinumab from cyclosporine A (CyA) in patients with psoriasis. The purpose of the present study was to assess the efficacy and safety of secukinumab for 16 weeks after direct switching from CyA in patients with moderate-to-severe psoriasis. In this multicenter, open-label, phase IV study, 34 patients with moderate-to-severe ps...